Metaplastic changes driven by prenatal cannabinoid exposure (PCE) on eCB signaling at excitatory afferents on dopamine neurons are identified and include a switch in retrograde signaling favoring de novo synthesis of nitric oxide (NO) to replace the actions of eCBs, which are compromised at excitatory inputs.
Excitatory synaptic plasticity within the nucleus accumbens (NAc) drives motivated behaviors, and dysregulation is implicated in several psychiatric disorders marked by impaired reward processing. The NAc integrates glutamatergic input, which conveys information about reward, context, and behavioral goals, with local G...
Ashley E. Copenhaver, Tara A. LeGates· bioRxiv· 0 citations
Midbrain dopamine (DA)-neurons are slow pacemakers that continuously fire action potentials, maintaining basal extracellular DA levels in target regions. The sodium leak channel NALCN has been identified as a key contributor in the pacemaker control of these neurons. However, the consequences of a disrupted DA pacemake...
Angelina Rogliardo, T. Le Borgne, A. Gulmez et al.· Journal of Physiology· 0 citations
The results suggest that glutamate cotransmission is a distinguishing feature of VTA dopamine neuron signaling patterns and roles in natural reward- or aversion-motivated behavior.
Emily D. Prévost, Lucy A Ward, Daniel Alas et al.· Science Signaling· 0 citations
The serotonin 2A receptor (5-HT
2A
) is a G
q/11
-coupled receptor implicated in reward processing, neuropsychiatric disorders, and the actions of serotonergic psychedelics. Although 5-HT
2A
activation has been shown to engage endocannabinoid (eCB) signaling in several brain regions, its role in inhibitory syna...
Camila Estay-Olmos, Koyam Morales-Weil, Juan Ahumada et al.· Frontiers in Pharmacology· 0 citations
Hypothalamic A11 dopamine neurons provide the only known source of spinal dopamine and critically modulate pain and motor systems. Yet, the electrophysiological properties of A11 neurons were unknown. Here, we characterized A11 dopamine neurons in mice using brain slice immunohistochemistry, and fluorescence-guided who...
Angela F. Smith, Hannah N. Rust, K. Sluka et al.· Neuropsychopharmacology· 0 citations
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