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Author

Valeria Serra

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Open access Aug 2026

Sex-specific effects of prenatal delta-9-tetrahydrocannabinol exposure on repetitive behavior and prefrontal cortex neuronal excitability in preadolescent rats

Cannabis is the most common illicit drug abused worldwide, and its consumption has substantially increased among pregnant women. We previously demonstrated that male preadolescent offspring prenatally exposed to Δ9-tetrahydrocannabinol (THC), a model of prenatal cannabinoid exposure (PCE), exhibit a mesolimbic dopamine...

S. Aroni, M. Di Bartolomeo, Valeria Serra et al. · 0 citations
Open access Sep 2026

An endocannabinoid-nitric oxide signaling switch triggers reciprocal inhibitory-excitatory plasticity at dopamine neuron inputs following prenatal cannabinoid exposure

Metaplastic changes driven by prenatal cannabinoid exposure (PCE) on eCB signaling at excitatory afferents on dopamine neurons are identified and include a switch in retrograde signaling favoring de novo synthesis of nitric oxide (NO) to replace the actions of eCBs, which are compromised at excitatory inputs.

Valeria Serra, F. Brandalise, Vivien Miczán et al. · 0 citations

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