István Katona

An endocannabinoid-nitric oxide signaling switch triggers reciprocal inhibitory-excitatory plasticity at dopamine neuron inputs following prenatal cannabinoid exposure

Metaplastic changes driven by prenatal cannabinoid exposure (PCE) on eCB signaling at excitatory afferents on dopamine neurons are identified and include a switch in retrograde signaling favoring de novo synthesis of nitric oxide (NO) to replace the actions of eCBs, which are compromised at excitatory inputs.