Aug 2026· Apoptosis· Vol 31· 2 citations· 158 references
Medicine
TL;DR
A “metabolic crisis-cascade” framework is proposed, in which progressive disruption of energy metabolism, redox balance, and metal homeostasis acts as a unifying upstream mechanism linking multiple PCD pathways during kidney injury and preventing AKI-to-CKD transition.
Ferroptosis is an iron-dependent form of programmed cell death defined by the lethal accumulation of lipid peroxides. Accumulating evidence indicates that ferroptosis plays a critical role in a wide range of pathological processes, including tumor progression, ischemia-reperfusion injury, and neurodegenerative diseases...
Myocardial ischemia–reperfusion injury (MIRI) is driven by dynamic metabolic disturbances that extend beyond adenosine triphosphate depletion and encompass mitochondrial dysfunction, redox imbalance, calcium overload, iron dysregulation, lipid peroxidation, and inflammatory activation. These alterations regulate multip...
Abstract Preeclampsia is a pregnancy-specific multisystem disorder in which placental stress is translated into maternal endothelial dysfunction, hypertension, and end-organ injury. This narrative review summarizes how six regulated cell death modalities—apoptosis, necroptosis, pyroptosis, ferroptosis, autophagic cell...
Rui Xiong, Ning Xu, Min Li et al.· International Journal of Gen...· 0 citations
A target-cell-oriented pharmacological map that integrates their autophagic targets, ferroptotic effects, disease contexts and relevant target-cell populations is constructed, thereby providing a rationale for developing ADF-based therapeutic strategies with defined indications, measurable pharmacodynamic biomarkers an...
Xiao Cui, Xinzhu Dong, Yang Li et al.· Pharmacological Research· 0 citations
The findings reveal a novel hierarchical cascade, mitochondrial ROS-driven ER stress leading to autophagic degradation of GPX4, as a core mechanism of Pb-induced hepatic ferroptosis, and TUDCA was identified as a potential therapeutic agent for Pb-induced hepatotoxicity.
Xinran Qiu, Wenjie Yang, Xue-Jun Wang et al.· Toxicology· 0 citations
This review examines the molecular crosstalk between oxidative stress and ferroptosis in ischemia–reperfusion injury and summarizes key pharmacological and natural agents that target these pathways to achieve neuroprotection.
Wasim Akhtar, Mohd Muazzam Khan, Sanjay Kumar et al.· Journal of Molecular Histolo...· 0 citations
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