TL;DR
This review examines the molecular crosstalk between oxidative stress and ferroptosis in ischemia–reperfusion injury and summarizes key pharmacological and natural agents that target these pathways to achieve neuroprotection.
Current evidence on the molecular mechanisms linking miRNAs and ferroptosis in SCI is summarized, highlighting how miRNA-mediated regulation of ferroptosis contributes to neuronal death, glial responses, and impaired regeneration, and discusses emerging therapeutic strategies targeting this axis to promote neuroprotect...
This review focuses on recent findings of perturbed metabolic processes in cancer that create a high iron demand and an altered lipid composition, thereby predisposing cells to ferroptosis and the therapeutic potential of pharmacological agents that can selectively trigger ferroptosis in tumor cells.
A contextual framework is built that specifies when HO-1 activation is protective versus detrimental, organised around three converging determinants: cell-type specificity, iron-handling capacity, and disease stage, which is extended to the often-overlooked dimensions of sex, age, and model heterogeneity, and used to i...
Although available evidence supports an association between ferroptosis-related processes and AD pathobiology, no single marker is sufficient to establish ferroptosis in human AD tissue, which restricts the diagnostic and therapeutic interpretation of ferroptosis in AD.
A multidimensional pathological network composed of multiple mitochondrial abnormalities, including mitochondrial reactive oxygen species bursts, Ca2+ overload and disruption of the mitochondrial quality control system, synergistically amplifies lipid peroxidation and drives neuronal ferroptosis across the pathophysiol...
A more complete understanding of the important role of selenoproteins in regulating liver pathological processes, particularly their antioxidant function, allows them to be considered as promising potential targets for the further development of pharmacotherapeutic strategies for the treatment of chronic liver diseases...
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