It is demonstrated that Sestrin2 has cardioprotective effects on obesity-associated HFpEF and is associated with the activation of adaptive IRE1α-XBP1 signaling involving Sigmar1, together with improved metabolic and redox homeostasis.
Ke-Xin Zhang, Cheng-Xia Kan, Jing-Wen Zhang et al.· Acta Biochimica et Biophysic...· 0 citations
Abstract Metabolic syndrome is frequently accompanied by anxiety and depression, suggesting interactions between metabolic dysfunction and affective regulation. Brain-derived neurotrophic factor (BDNF) and its high-affinity receptor tropomyosin receptor kinase B (TrkB) are involved in energy balance, neuroplasticity, s...
Chang Liu, Chen Sun, Cheng-Xia Kan et al.· Reviews in the Neurosciences· 0 citations
Immunotherapy has transformed cancer treatment, yet its efficacy in solid tumors remains constrained by primary or acquired resistance. Increasing evidence suggests that ferroptosis sensitivity is shaped not only by tumor intrinsic metabolic programs but also by the surrounding microenvironment. Ferroptosis, an iron-de...
Wan-Qiu Zhang, Xiao-Fei Zhang, Si-Lin Kong et al.· Cellular Reprogramming· 0 citations
AIP is a key mediator linking proinflammatory diets to MetS, supporting the diet–inflammation–lipid axis and identifying targets for precision prevention.
Jiajun Sang, Ke-Xin Zhang, Cheng-Xia Kan et al.· Metabolic Syndrome and Relat...· 0 citations
A deeper mechanistic understanding of HOX-driven networks will aid the development of innovative biomarkers and therapies, thereby advancing precision medicine in endocrine oncology, and advancing precision medicine in endocrine oncology.
Si-Lin Kong, Ke-Xin Zhang, Cheng-Xia Kan et al.· Medical Oncology· 0 citations
A “metabolic crisis-cascade” framework is proposed, in which progressive disruption of energy metabolism, redox balance, and metal homeostasis acts as a unifying upstream mechanism linking multiple PCD pathways during kidney injury and preventing AKI-to-CKD transition.
Jiajun Sang, Zhen-Tao Guo, Cheng-Xia Kan et al.· Apoptosis· 2 citations
This study suggests that IL‐12p40 is probably one of the factors correlated with HT etiology, contributing to a better understanding of the pathogenesis of HT and underscoring the potential for therapeutic interventions targeting inflammatory proteins.
Shu-Ting Ding, Wei-Qiang Su, Ming-Hao Wu et al.· Mediators of Inflammation· 0 citations
The G20 has achieved substantial but uneven reductions in IHD burden, with early signs of reversal, demographic pressures, and expanding environmental risks, but targeted, stage-specific cardiovascular strategies will be required to sustain progress and reduce disparities through mid-century.
Yan-Jia Shi, Kexin Zhang, Si-Jing Tang et al.· Catheterization and cardiova...· 1 citation
The global burden of NMSC is rising, and men consistently experience higher incidence, mortality, and DALY rates than women, and the expanding sex gap highlights the urgent need for targeted and sex-specific prevention, early detection, and public health interventions.
Wenqiang Zhang, Ke-Xin Zhang, Cheng-Xia Kan et al.· Advances in Skin & Wound Car...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
