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#protein folding Open access

Topological Protection as the Organizing Principle of Threshold-Gated Regulation: From Quantum Integers to Macroscopic Coherence (CMF Paper 3)

Sep 2026 · Zenodo (CERN European Organization for Nuclear Research)
Topological Materials and Phenomena

Abstract

The Coherence Maintenance Framework (CMF), established in Papers 1 and 2, demonstrates that threshold-gated regulatory architecture is a universal feature of driven non-linear systems across 29 orders of magnitude in scale. While R_mode = f_pert * tau_relax quantitatively categorizes regulatory dynamics into discrete operational regimes, a fundamental theoretical question remains: why are threshold responses strictly discrete and all-or-nothing? Here we show that CMF thresholds (S_critical) are not arbitrary energy barriers that can be continuously eroded by thermal or quantum noise, but rather topological barriers governed by conserved integer-valued global invariants. We present a taxonomy of three distinct constraint categories: (1) Strict Topological Protection (winding numbers l, Q, Chern numbers C, flux quanta Phi_0), (2) Thermodynamic Constraint Universality (protein folding energy landscapes, Arrhenius kinetics), and (3) Geometric Global Constraints (phase-space attractors, spatial boundary conditions). To explain how microscopic topological invariants survive environmental decoherence, we formulate the Staging Hypothesis: intermediate physical structures (staging layers) selectively transmit globally encoded topological invariants while shedding local uncorrelated noise as information propagates upward. We substantiate this framework using a series of 2026 experimental benchmarks, including liquid crystal toron orbital angular momentum lasing, flat-band compact molecular orbitals, real-space STM imaging of obstructed atomic insulators, chiral phonon transport in alpha-quartz, and QCD vacuum spin correlations at the STAR detector (10^-18 m). Finally, we connect topological protection to renormalisation group universality, proving that substrate independence is an inevitable mathematical consequence of global topological invariants in driven open systems.

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