Skip to content
Log in
Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Similar papers

Jul 2026

An electrochemiluminescent sensor based on ZnPTC@MoS2 nanocomposite for sensitive determination of trilobatin.

In this work, a sensitive electrochemiluminescence (ECL) sensing platform was developed for the determination of trilobatin (Tri) using a ZnPTC@MoS2-modified glassy carbon electrode. In this sensing interface, ZnPTC acts as both an intrinsically ECL-active metal-organic framework and a structural scaffold, while MoS2 nanosheets promote interfacial electron transfer and facilitate the electroreduction of persulfate. The synergistic integration of ZnPTC and MoS2 effectively alleviates the restacking of MoS2 nanosheets, improves charge-transfer kinetics, and significantly enhances the ECL response of the composite. Under the optimized experimental conditions, the change in ECL intensity showed a good linear relationship with the logarithm of Tri concentration over the range of 5.0 × 10-8-1.0 × 10-3 M, with a detection limit of 5.6 × 10-9 M. The proposed ECL sensor exhibited good selectivity, reproducibility, operational stability, and long-term stability. Moreover, the method was successfully applied to the determination of Tri in real samples, affording recoveries of 98.98-103.66% with relative standard deviations below 2.50%. These results demonstrate that the ZnPTC@MoS2-based ECL platform provides a promising analytical strategy for sensitive Tri determination in practical samples.

Xiaohui Chen, Xue Mei, Wen-Chang Wang et al. · 0 citations
Aug 2026

A dual-quenching electrochemiluminescence immunosensor based on ABEI@Fe3O4@PDA-PdPt and Cu2−xS nanoflowers for sensitive detection of galectin-3

This work presents a novel strategy for the highly sensitive detection of Gal-3, leveraging the synergistic dual-quenching mechanism to achieve excellent analytical performance, thereby holding significant promise for clinical diagnostics and early disease monitoring applications.

Tingting Ye, Zhu Wang, Xinxin Chen et al. · 0 citations
Jul 2026

A highly sensitive electrochemical immunosensor based on a g-C₃N₄/MgO nanocomposite for ultrasensitive detection of CYFRA21-1

A sensitive and label-free electrochemical immunosensor based on a g-C₃N₄/MgO nanocomposite-modified electrode for the selective detection of CYFRA21-1 has great promise for clinical diagnosis and point-of-care detection of lung cancer biomarkers because of its affordability, simplicity, and sensitivity.

Pooja Rahar, Saravjeet Singh · 0 citations
Sep 2026

Triple-ligand engineered gold nanoclusters with aggregation-induced emission for a high-sensitivity arginase activity electrochemiluminescence biosensor.

Sensitive and accurate monitoring of arginase activity is significant for clinical diagnosis. Herein, a dual-enhanced aggregation-induced electrochemiluminescence (ECL) biosensor was constructed based on triple-ligand-protected gold nanoclusters (AuNCs), sequentially coating 6-aza-2-thiothymine-capped AuNCs with L-arginine (Arg) and tetraoctylammonium bromide (TOAB). This ligand-engineering strategy restricted molecular vibrations and rotations while enhancing electron transfer efficiency, leading to a stepwise increase in ECL efficiency from 23% to 30% and finally to 71%. The hydrolysis of Arg, catalyzed by arginase, leads to dramatic quenching in the dual-enhanced ECL signal, forming the basis for quantitative detection of arginase activity. It achieved an ultra-low detection limit of 1.23 × 10-7 U mL-1 with a broad linear range from 1 × 10-6 to 0.02 U mL-1. The system showed excellent selectivity, stability, and reproducibility and was successfully applied to determine arginase activity in human serum. Triple-ligand AuNCs with dual-enhanced aggregation-induced ECL open a new avenue for constructing high-performance ECL detection platforms.

Li-Li Tong, Xue-Ke Luo, Yan Zhang et al. · 0 citations
Open access Aug 2026

Immunosensor Based on Gold Nanoparticles Encapsulated in Azo-Polymer and Reduced Graphene Oxide for the Detection of the Proinflammatory Molecule Interleukin-6.

Rapid interleukin-6 (IL-6) monitoring is essential for the early diagnosis and management of inflammatory and oncological conditions. This study reports a label-free impedimetric immunosensor based on a ternary poly(azo-BBY)-AuNP/rGO nanocomposite synthesized via a single-step electrochemical process. The platform utilizes dissolved oxygen as an intrinsic redox probe, precluding the need for external mediators. Morphological characterization confirmed a synergistic architecture where gold nanoparticles are encapsulated within the polymeric matrix and covered by a reduced graphene oxide veil, reducing charge-transfer resistance by over 90%. The immunosensor achieved a detection limit of 2.51 pg mL-1 with a linear range between 5 and 30 pg mL-1. A thermodynamic investigation via the Freundlich isotherm revealed a dual-stage adsorption mechanism and a steric "gate effect". Selectivity assays demonstrated high specificity, including the competitive displacement of IL-6 by the IL-1 receptor antagonist (IL-1RA). Practical utility was validated in cell culture, yielding results statistically equivalent to the ELISA gold standard. Operational stability was established for 4 days within a 95% confidence interval (97.2%-115.1%). These findings support the proposed platform as a proof-of-concept label-free immunosensor for IL-6 monitoring.

Gabriel M. Silva, Pedro C. M. Pizzol, F. Lira et al. · 0 citations
Sep 2026

An electrochemiluminescent aptasensor based on porphyrin-based covalent organic framework for the sensitive detection of kanamycin.

Herein, an electrochemiluminescent (ECL) aptasensor based on porphyrin-based covalent organic framework (TP-COF) was constructed for the ultrasensitive detection of kanamycin (KANA). The ordered porous channels and porphyrin-centered π-conjugated framework of TP-COF optimize the interfacial microenvironment and accelerate electron transfer, facilitate the generation of luminol-derived active intermediates, and remarkably boost ECL emission. The modification of Au NPs on the surface of COF could improve interfacial conductivity and provide anchoring sites for thiolated DNA immobilization. Platinum-copper nanocages (PtCu) were employed as an ECL quencher and assembled onto the electrode via DNA hybridization to generate the initial "light-off" state. Upon target recognition, the aptamer was preferentially bind with KANA to dissociate PtCu from the electrode surface and restore the ECL signal. Under the optimal condition, the sensor exhibited linear response toward KANA over the range of 1.0 × 10-15 to 1.0 × 10-13 mol L-1, with a detection limit of 8.9 × 10-16 mol L-1. In addition, the satisfactory repeatability, stability, and selectivity were achieved. This strategy integrates COF-mediated interfacial regulation, noble-metal-assisted signal amplification, and aptamer-triggered dequenching, offering a promising platform for the ultrasensitive analysis of antibiotic residues.

Unknown authors · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.