An electrochemiluminescent sensor based on ZnPTC@MoS2 nanocomposite for sensitive determination of trilobatin.

Abstract

In this work, a sensitive electrochemiluminescence (ECL) sensing platform was developed for the determination of trilobatin (Tri) using a ZnPTC@MoS2-modified glassy carbon electrode. In this sensing interface, ZnPTC acts as both an intrinsically ECL-active metal-organic framework and a structural scaffold, while MoS2 nanosheets promote interfacial electron transfer and facilitate the electroreduction of persulfate. The synergistic integration of ZnPTC and MoS2 effectively alleviates the restacking of MoS2 nanosheets, improves charge-transfer kinetics, and significantly enhances the ECL response of the composite. Under the optimized experimental conditions, the change in ECL intensity showed a good linear relationship with the logarithm of Tri concentration over the range of 5.0 × 10-8-1.0 × 10-3 M, with a detection limit of 5.6 × 10-9 M. The proposed ECL sensor exhibited good selectivity, reproducibility, operational stability, and long-term stability. Moreover, the method was successfully applied to the determination of Tri in real samples, affording recoveries of 98.98-103.66% with relative standard deviations below 2.50%. These results demonstrate that the ZnPTC@MoS2-based ECL platform provides a promising analytical strategy for sensitive Tri determination in practical samples.