A Time-Resolved Single-Cell Atlas Reveals Infection-Status, Age-, and Sex-Dependent Immune Responses Drive Viral Disease Severity

Lu-Jia Chen Aodong Qiu Jooyoung Kim Nebal AbuHusein Mengyao Lu K. Agaronyan Ke-Xin Sun Yi-Fan Yuan A. Zhao Gagan O. Heda Xing-Hua Lu Georgios D. Kitsios Alicia N. Rizzo William Bain T. Nyunoya Tomeka L Suber J. Evankovich F. Shah C. D. Cruz E. Manning Lokesh Sharma

Aug 2026 · bioRxiv · 0 citations · 9 references

Biology

TL;DR

Time-resolved single-cell RNA sequencing across 16 conditions spanning age, sex, and four stages of influenza infection in mice generates a high-resolution atlas, revealing how infection status of the cell, age, and sex interact to drive persistent inflammation and impaired resolution.

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