Multiple factors associated with the AD are discussed, such as Aβ, oxidative stress, and inflammatory signaling, contributing to the phosphorylation, ubiquitination, internalization, and degradation of P-gp, which results in impaired transporter function and a compromised integrity of the BBB.
The review elucidates the molecular mechanisms linking ferroptosis and NMDA receptor overactivation and their impact on P‐gp‐mediated Aβ transport in the AD, providing integrated mechanisms and harnessing their potential for AD therapeutics.
Jotiram Salunkhe, Dr. Vinod Ugale· Drug development research (P...· 0 citations
Alzheimer's disease (AD) is characterized by progressive cognitive decline driven by the convergence of tauopathy, impaired proteostasis, and chronic neuroinflammation. Emerging evidence identifies the immunoproteasome (iP), particularly the β5i/LMP7 subunit, as a central regulator linking these pathological processes....
Mustafa M. Shokr, Ahmed M. Abdelaziz· InflammoPharmacology· 0 citations
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-beta (Aβ) plaques and neurofibrillary tangles. Beyond these hallmark pathological features, the complex pathogenesis of AD involves cellular dysfunctions associated with chronic oxidative stress and neuroin...
Song-I. Seol, Ji-Eun Kim, Dashdulam Davaanyam et al.· International Journal of Mol...· 0 citations
This review examines the molecular and cellular mechanisms through which neuroinflammation contributes to the progression of AD, with particular emphasis on microglial activation, TREM2 and soluble TREM2 (sTREM2) signaling, NLRP3 inflammasome activation, astrocyte–microglia interactions, and blood–brain barrier dysfunc...
Shreyansh Goswami· International Journal For Mu...· 0 citations
Abstract Clinically distinct neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS), share in common progressive neuronal dysfunction and cell death associated with the accumulation of misfolded proteins. Central to these processes are the cellul...
James F. Morley· Philosophical transactions o...· 0 citations
The phenotypic and functional alterations of B cells in AD are reviewed, integrating evidence from experimental models and human studies to evaluate whether B cells constitute an underappreciated component of the adaptive immune response in AD and whether they represent a compelling immunotherapeutic target.
Eva-Loren Charavner, S. Fillatreau, M. El Behi· Cellular Immunology· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
