Aditi Joshi

UPS-mediated P-glycoprotein regulation in Alzheimer’s disease: pharmacological implications for the amyloid pathology

Multiple factors associated with the AD are discussed, such as Aβ, oxidative stress, and inflammatory signaling, contributing to the phosphorylation, ubiquitination, internalization, and degradation of P-gp, which results in impaired transporter function and a compromised integrity of the BBB.