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Pathological Th2 cell activation via STAT6 pathway for pulmonary fibrosis.

Yudai Miyashita T. Kaiho Raul Piseaux Aillon Ka Lam Nguyen Megan E. Kelly Xin Wu Nikita Mehta Elora Hossain Taichi Nagano Y. Yagi Rizaldy P. Scott Yuan-Qing Yan Hai-Ying Sun Carl Atkinson Benjamin D. Singer G. R. Scott Budinger A. Bharat C. Kurihara
Sep 2026 · American Journal of Respiratory Cell and Molecular Biology · 0 citations
Medicine

TL;DR

A CD28-JAK1/STAT6-Th2-monocyte-derived alveolar macrophage pathway is defined as a mechanistic driver of pulmonary fibrosis and nominate CD28 and STAT6 as actionable immunologic targets that could complement existing antifibrotic therapies.

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