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A CD28-JAK1/STAT6-Th2-monocyte-derived alveolar macrophage pathway is defined as a mechanistic driver of pulmonary fibrosis and nominate CD28 and STAT6 as actionable immunologic targets that could complement existing antifibrotic therapies.
Systematic assessment of thoracic structures already imaged during coronary calcium screening CT, combined with reliable guideline-concordant pulmonary nodule follow-up, may complement existing lung cancer screening by enabling earlier detection among patients outside current screening eligibility.
Hypercapnia, elevated carbon dioxide (CO2), is common in advanced chronic obstructive pulmonary disease (COPD) and predicts poor clinical outcomes. Traditionally considered a consequence of disease severity, hypercapnia may drive disease progression by promoting airway dysfunction. Here, we show that hypercapnia acts a...
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