TL;DR
The findings demonstrate that indole-benzimidazole hybrids function as multifunctional modulators of breast cancer cell metabolism by coordinately targeting lipid homeostasis, sphingolipid-associated signaling, autophagic regulation, and apoptosis.
Colorectal cancer (CRC), a significant malignancy of the digestive system, represents a considerable threat to global health. Currently, its clinical efficacy is often limited by tumor heterogeneity and therapeutic resistance. Lipid metabolic reprogramming has been identified as a core process in CRC, not only providin...
Salidroside, a phenylethanol glycoside and principal bioactive constituent of Rhodiola rosea, has emerged as a promising multi-target anti-tumor agent with significant effects on cancer energy metabolism. This review summarizes and analyzes the mechanisms it uses to reprogram tumor energy metabolism. Recent studies sho...
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, necessitating the identification of novel small molecules capable of targeting multiple survival pathways. In this study, the antiproliferative potential of dds benzimidazole-palladium (Pd) complexes was evaluated across breast cance...
Initial evidence is provided that marbofloxacin induces metabolic and molecular rewiring in BC, highlighting its promise as a repositionable therapeutic candidate.
AIM OF THE STUDY Non-small cell lung cancer (NSCLC) accounts for the vast majority of lung cancer cases and remains a therapeutic challenge due to drug resistance, adverse effects, and metabolic plasticity. Icariin (ICR), a principal bioactive flavonoid from Epimedium, exhibits promising antitumor properties; however,...
Colorectal cancer (CRC) continues to pose a significant global health concern, largely driven by metabolic reprogramming mechanisms that facilitate tumor progression and enable immune evasion within the tumor microenvironment (TME). This review highlights the pivotal functions of dysregulated metabolic pathways, such...
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