Cancer is one of the leading causes of morbidity and mortality worldwide, with lung cancer ranked among the most lethal malignancies. A key hallmark of cancer progression is neovascularization, primarily mediated by vascular endothelial growth factor (VEGF), which stimulates vasculogenesis and angiogenesis. In parallel...
Berrin Ozdil, E. Acikgoz, G. Oktem et al.· Applied immunohistochemistry...· 0 citations
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, necessitating the identification of novel small molecules capable of targeting multiple survival pathways. In this study, the antiproliferative potential of dds benzimidazole-palladium (Pd) complexes was evaluated across breast cance...
Mustafa Çakır, E. Acikgoz, B. Kuzu et al.· Molecules· 0 citations
The findings demonstrate that indole-benzimidazole hybrids function as multifunctional modulators of breast cancer cell metabolism by coordinately targeting lipid homeostasis, sphingolipid-associated signaling, autophagic regulation, and apoptosis.
E. Acikgoz, Mustafa Çakır, B. Kuzu· Naunyn-Schmiedeberg's Archiv...· 0 citations
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