Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, necessitating the identification of novel small molecules capable of targeting multiple survival pathways. In this study, the antiproliferative potential of dds benzimidazole-palladium (Pd) complexes was evaluated across breast cance...
Mustafa Çakır, E. Acikgoz, B. Kuzu et al.· Molecules· 0 citations
Findings indicate that quinine suppresses MCF-7 cell growth and migration by downregulating PD-L1 and STAT3 gene expression, reducing VEGF levels, and increasing TINAGL-1 levels, highlighting the compound’s potential for PD-L1 inhibition in cancer.
Fuat Karakuş, Sedat Köstekci, B. Kuzu et al.· International Journal of Sec...· 1 citation
The findings demonstrate that indole-benzimidazole hybrids function as multifunctional modulators of breast cancer cell metabolism by coordinately targeting lipid homeostasis, sphingolipid-associated signaling, autophagic regulation, and apoptosis.
E. Acikgoz, Mustafa Çakır, B. Kuzu· Naunyn-Schmiedeberg's Archiv...· 0 citations
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