Single-cell Profiling of Lymphoid and Myeloid Compartments Reveals Coordinated Immune Dysregulation and Enhanced Monocyte-centric Intercellular Communication in Relapsing Polychondritis.

Single-cell transcriptomic analysis reveals systemic immune dysregulation and identifies PLEK as a candidate hub gene associated with CD8+ T-cell activation in myasthenia gravis.

This study provides a systems-level view of immune dysregulation in MG, highlighting enhanced intercellular communication, T-cell dysregulation, and PLEK as a potential molecular marker associated with CD8+ T-cell activation and disease severity, offering insights into MG pathogenesis and therapeutic targets.

Tfh cell communication with myeloid compartments plays a key role in the inflammatory response in localized scleroderma: insights from skin scRNA sequencing.

Macrophages, T lymphocytes and NK cells are central to inflammatory responses in localized scleroderma (LS morphea), but their inflammatory signature and differentiation remain inadequately classified. This study examined the transcriptomes of these cell types to clarify their contribution to LS pathogenesis. Single-ce...

T-cell and monocyte DNA methylation and Wnt dysregulation in common variable immunodeficiency: an exploratory study

Many patients with common variable immunodeficiency (CVID) develop inflammatory/autoimmune complications associated with T-cell and monocyte dysregulation which may involve epigenetic modifications. To characterize genome-wide CpG methylation in CD3 + T-cells and CD14 + monocytes in CVID and relate epi...

Monocyte–plasma cell communication characterizes treatment-associated peripheral immune remodeling in Guillain–Barré syndrome

Background Guillain -Barré syndrome (GBS) is an acute immune-mediated polyradiculoneuropathy involving multifaceted pathogenic mechanisms. Although humoral immunity is central to GBS pathogenesis, longitudinal changes in peripheral immune circuits across symptomatic disease and clinical recovery remain incompletely und...

Single-cell transcriptomic profiling of cerebrospinal fluid reveals immune-cell heterogeneity and multicompartment MIF/CD74-related communication in tuberculous and purulent meningitis

Background Tuberculous meningitis (TBM) is a severe central nervous system infection in which dysregulated host inflammation contributes to neurological injury. The cellular organization of the cerebrospinal fluid (CSF) immune microenvironment in TBM, particularly in comparison with other inflammatory meningitis condit...

Single-cell RNA profiling suggests goflikicept-mediated immune modulation in idiopathic recurrent pericarditis