Single-cell Profiling of Lymphoid and Myeloid Compartments Reveals Coordinated Immune Dysregulation and Enhanced Monocyte-centric Intercellular Communication in Relapsing Polychondritis.
A comprehensive, cell-type-revolved atlas of peripheral immune dysregulation in RP is delineated, revealing coordinated alterations in T cell activation and redistribution, B cell differentiation, myeloid-driven inflammation, and prominent alarmin-related signatures.