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Author

Jie-Ruo Gu

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Aug 2026

Single-cell profiling reveals senescent bone marrow mesenchymal stem cell subpopulations driving pathological ossification in ankylosing spondylitis.

OBJECTIVES Aberrant new bone formation is a hallmark of ankylosing spondylitis (AS), yet the cellular mechanisms remain unclear. Bone marrow-derived mesenchymal stem cells (BMSCs) are crucial for skeletal homeostasis and may be pathologically reprogrammed under chronic inflammation. We aimed to characterize the cellula...

Xi-Qing Luo, Jinwei Li, J. Qi et al. · 0 citations
Aug 2026

Single-cell Profiling of Lymphoid and Myeloid Compartments Reveals Coordinated Immune Dysregulation and Enhanced Monocyte-centric Intercellular Communication in Relapsing Polychondritis.

A comprehensive, cell-type-revolved atlas of peripheral immune dysregulation in RP is delineated, revealing coordinated alterations in T cell activation and redistribution, B cell differentiation, myeloid-driven inflammation, and prominent alarmin-related signatures.

Chenyang Lu, Yao Liang, Simin Xu et al. · 0 citations

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