Review

Castration-resistant prostate cancer as an adaptive tumor ecosystem: coupling tumor evolution with microenvironmental reprogramming

Si-Liang Wang Xin-Yi Xu Ming-Huang Xu Yuang Wei Yun-Xiao Qiao Xiao-Wen Song Chuang Xie Chun-Mei Zhou Fu-Wen Yuan

Sep 2026 · Cancer Metastasis Review · Vol 45 · 0 citations · 209 references

Medicine

TL;DR

A system-level framework is proposed in which CRPC is viewed as an adaptive tumor ecosystem shaped by evolutionary selection, cellular plasticity, and microenvironmental co-evolution under therapeutic pressure and therapeutic strategies aimed at reprogramming or destabilizing adaptive tumor ecosystems are highlighted.

DOI PubMed Semantic Scholar

View source

Similar papers

Review Open access Sep 2026

Tumor-immune spatiotemporal co-evolution: A new paradigm for understanding and overcoming therapy resistance in metastatic castration-resistant prostate cancer (Review)

S spatiotemporal co-evolution is established as a unifying framework that transforms mCRPC from a uniformly fatal disease into a chronically manageable condition through precisely timed, spatially informed and mechanistically rational interventions.

Li Yan, Xiao-Ke Sun, Peng-Xiao Su · International Journal of Mol... · 0 citations

Review Sep 2026

Metabolic plasticity in castration-resistant prostate cancer: reprogramming mechanisms and therapeutic opportunities.

The metabolic network, regulatory mechanism, and current challenges of CRPC are discussed in order to provide a theoretical basis for clinical prevention and treatment.

Yanzhi Lou, Zhengda Lou, Luo He et al. · Cellular Signalling · 0 citations

Review Sep 2026

Overcoming cancer resistance in pancreatic cancer: toward dynamic precision oncology

A Dynamic Precision Oncology (DPO) framework is proposed that extends conventional precision oncology beyond baseline molecular profiling by integrating longitudinal assessment of tumor genomics, circulating tumor DNA, CA19-9, imaging, radiomics, and clinical characteristics and summarizes emerging strategies for overc...

Takehiro Okabayashi, Motoyasu Tabuchi, Teppei Tokumaru et al. · Molecular Biology Reports · 0 citations

Review Open access Aug 2026

Single-cell and spatial omics of metabolic-immune ecosystems in prostate cancer: from androgen signaling to therapy resistance

This review synthesizes single-cell and spatial omics evidence for metabolic-immune ecosystems in prostate cancer, emphasizing the transition from androgen dependence to castration resistance, lineage plasticity, metastatic niche adaptation, and therapy resistance.

Rui-An Wang, Yi-Fan Li, Xiaoxiang Wang · Frontiers in Immunology · 1 citation

Review Aug 2026

Transforming Cancer Treatment: Integrative Strategies Targeting the Tumor Microenvironment through Biological Innovation and Artificial Intelligence.

This review comprehensively examines the cellular and acellular architecture of the TME, emphasizing its spatial organization, metabolic reprogramming, mechanical properties, and immunological regulation across diverse tumor types.

R. Latif, Taufiq Nawaz · Critical reviews in oncology... · 0 citations

Review Open access Sep 2026

Stemness plasticity in hepatocellular carcinoma: spatial niches and therapeutic implications.

Current evidence linking stemness plasticity to spatial niche regulation and treatment failure in HCC is synthesized, and a therapeutic framework that integrates targeting of intracellular regulatory programs with disruption of microenvironmental support systems is outlined.

H. Ahn, Sujin Kim, H. Cho · Journal of Liver Cancer · 0 citations