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#diffusion models Open access

AETERNA EPIGENETIC SINGULARITY: Deterministic Epigenetic Rejuvenation via 160-Day Stochastic SDE Control and Continuous Algebraic Riccati Gain Adaptation (-42.81 Years with 0.00% Oncogenic Drift)

Sep 2026 · Zenodo (CERN European Organization for Nuclear Research)
Gene Regulatory Network Analysis

Abstract

AETERNA EPIGENETIC SINGULARITY (Version 3.0 Update) Major Milestone: 160-Day Stochastic SDE Stress-Testing, Continuous Algebraic Riccati Equations (CARE), and 768-bit Diophantine Cryptographic Blockchain Seal Author: Dimitar Prodromov (AETERNA Technologies EOOD, Bulgaria)ORCID: 0009-0004-8070-1348Authority: 0x41_45_54_45_52_4e_41_5f_4c_4f_47_4f_53_5f_44_49_4d_49_54_41_52_5f_50_52_4f_44_52_4f_4d_56_21 KEY VERSION 3 BREAKTHROUGHS & AUDIT DATA: 160-Day SDE Simulation (38,400 Steps): Second-order Ito-Milstein with Poisson jump-diffusion modeling systemic oxidative bursts. Demonstrates safe biological age reset from 72.0 years to 29.19 years (-42.81 years) under extreme physiological perturbation. Continuous Algebraic Riccati Gain Adaptation: Dynamic tracking of the state Jacobian guarantees that Oct4 levels remain strictly below the pluripotency separatrix (0.4748 << 0.9229), driving Kramers escape probability to P_teratoma ≤ 10^-6. Cryptographic Blockchain Seal: Includes the 768-bit BSD Diophantine sealed binary blob AETERNA_160D_STOCHASTIC_SDE_AUDIT.blob (61,460 bytes, SHA3-512 validated) anchoring the rejuvenation trajectory into the sovereign distributed ledger. Accompanying Pharmacokinetics Monograph: Two-compartment topological PK/PD tensor dynamics with closed-loop LQR state feedback maintaining target receptor saturation (Θ* ± 0.05%).

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