This review critically examines the molecular and cellular mechanisms underlying PE-mediated adipose–brain crosstalk in obesity-associated Alzheimer’s disease, with emphasis on mitochondrial dysfunction, blood–brain barrier disruption, ferroptosis, membrane remodeling, and microglial activation.
This chapter addresses the gap and consolidates existing information connecting lipid modifications to metabolic dysfunction in AD, emphasizing molecular pathways and prospective treatment strategies aimed at lipid metabolism to re-establish bioenergetic equilibrium.
Nitin Yadav, Jyotirmoy Banerjee, Manisha Tiwari et al.· International review of neur...· 0 citations
The chapter outlines the current evidences on dysregulated metabolic processes, and highlights emerging metabolic biomarkers that are identified through advanced neuroimaging modalities, plasma/cerebrospinal fluid (CSF) profiles, lipidomic signatures and markers of mitochondrial impairment, underscoring their diagnosti...
Radhika Mittal, Priya, Jyotirmoy Banerjee et al.· International review of neur...· 0 citations
Overall, this review makes a case for integrative, pathway-based therapeutic models, and multiple approaches may facilitate for drug development, biomarker identification and patient management in Alzheimer's disease.
Lipids are essential for brain structure and function, contributing to membrane integrity, synaptic activity, signal transduction, and energy metabolism. Converging evidence from human genetics, epidemiology, lipidomics, and neuroimaging indicates that disrupted lipid homeostasis is an early and biologically rele...
L. Berliocchi, M. Grimm, Tobias Hartmann et al.· BMC Medicine· 0 citations
A organelle-centered perspective will clarify AD pathogenesis and help guide the development of next-generation neuroprotective therapies, and highlight the essential requirements for building one, centered on synaptic mitochondrial bioenergetics and quality control.
Yu-Xin Wang, Wei-Dong Wu, Li-Shuang Yan et al.· Frontiers in Pharmacology· 0 citations
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