AD blood‐based biomarker–cognition associations were domain‐differentiated and context‐dependent: Concurrent associations did not reliably indicate associations with cognition 6 years later, and only p‐tau181 showed formal evidence of relative memory‐versus‐executive selectivity.
Abstract
Whether Alzheimer's disease (AD) blood biomarker–cognition associations differ across cognitive domains, analytic context, and biomarker modeling strategy in population‐based cohorts is unclear.
Vascular markers showed statistically robust but small group‐level differences with no individual‐level discriminative utility, and their divergent 12‐month trajectories require replication over longer follow‐up before they can be interpreted as stage‐dependent regulation.
Higher plasma YKL‐40 was associated with greater white matter hyperintensity (WMH), whereas higher plasma GFAP was related to increased 18F‐florbetapir (FBP) standardized uptake value ratio (SUVR) and higher plasma p‐tau217 was associated with reduced MTL cortical thickness and hippocampal volume.
Batool Rizvi, Jenna N. Adams, Alison R. Bamford et al.· Alzheimer's & Dementia· 1 citation
Overall, the pattern of associations varied by biomarker modality, IC domain, and study design, suggesting that AD-related pathology and neurodegeneration have functional correlates beyond cognition.
BAG is a reliable non-invasive marker of structural brain health sensitive to AD pathology and to modifiable AD risk and supports its relevance for early risk stratification and prevention-oriented research.
E. Kuhn, G. Antopoulos, L. Kleineidam et al.· medRxiv· 0 citations
Abstract INTRODUCTION Cross‐sectional studies link Alzheimer's disease (AD) pathogenesis to mild behavioral impairment (MBI), but longitudinal evidence remains limited. We examined whether plasma phosphorylated tau (p‐tau)181 predicts progression of an MBI‐proxy over 2 years in pre‐frail and frail older adults with mil...
F. Bellelli, E. González, Alberta Peluso et al.· Alzheimer's & Dementia· 0 citations
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