Author

James E. Galvin

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Sep 2026

A blood DNA methylation marker of cognitive ability is associated with six-year cognitive performance independent of blood Alzheimer's disease biomarkers.

Preliminary evidence is provided that a cognition-trained DNAm signature captures variation in later cognitive performance not fully represented by baseline cognition or available ADRD blood biomarkers.

Deirdre M. O'Shea, Lily Wang, David Lukacsovich et al. · The journals of gerontology.... · 0 citations

Open access Jul 2026

Comparative analyses of Alzheimer's disease blood biomarkers and cognitive domains

AD blood‐based biomarker–cognition associations were domain‐differentiated and context‐dependent: Concurrent associations did not reliably indicate associations with cognition 6 years later, and only p‐tau181 showed formal evidence of relative memory‐versus‐executive selectivity.

Deirdre M. O'Shea, James E. Galvin · Alzheimer's & Dementia · 0 citations