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Author

Deirdre M. O'Shea

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Review Open access Oct 2026

Limitations of current neuroprotective therapies in dementia with Lewy bodies.

INTRODUCTION Dementia with Lewy bodies (DLB) is characterized by progressive cognitive, neuropsychiatric, motor, autonomic, and sleep impairment. Pharmacological interventions developed with disease-modifying intent have entered clinical testing, but their biological rationale and adequacy of evaluation remain uncertai...

Deirdre M. O'Shea, Shanell Disla, Alyssa Gosling et al. · 0 citations
Sep 2026

A blood DNA methylation marker of cognitive ability is associated with six-year cognitive performance independent of blood Alzheimer's disease biomarkers.

Preliminary evidence is provided that a cognition-trained DNAm signature captures variation in later cognitive performance not fully represented by baseline cognition or available ADRD blood biomarkers.

Deirdre M. O'Shea, Lily Wang, David Lukacsovich et al. · 0 citations
Open access Jul 2026

Comparative analyses of Alzheimer's disease blood biomarkers and cognitive domains

AD blood‐based biomarker–cognition associations were domain‐differentiated and context‐dependent: Concurrent associations did not reliably indicate associations with cognition 6 years later, and only p‐tau181 showed formal evidence of relative memory‐versus‐executive selectivity.

Deirdre M. O'Shea, James E. Galvin · 0 citations

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