A systematic review and meta-analysis comparing the clinical outcomes of the Watchman FLX versus Watchman 2.5 device for transcatheter left atrial appendage occlusion in patients with atrial fibrillation.
Jul 2026· Critical Pathways in Cardiology· 0 citations
Medicine
TL;DR
The Watchman FLX is associated with significantly superior safety and efficacy outcomes relative to the Watchman 2.5 across the principal clinical domains of transcatheter LAAO.
BACKGROUND
Long-term oral anticoagulation remains the standard of care for patients with atrial fibrillation, despite the non-negligible risk of bleeding. Percutaneous left atrial appendage closure (LAAC) has emerged as an alternative strategy for preventing stroke with inconclusive modern data.
AIMS
Our aim was to e...
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BACKGROUND
Stroke prevention after transcatheter aortic valve replacement (TAVR) in patients with atrial fibrillation remains clinically challenging because thromboembolic risk must be balanced against substantial bleeding vulnerability. Left atrial appendage occlusion (LAAO) has been proposed as a nonpharmacologic alt...
Mustafa Abomohsen, Amr Elboliney, A. Mohamed et al.· Journal of Cardiology· 0 citations
LAAO demonstrated efficacy comparable to DOAC therapy in reducing the risk of MACCE, NACE, and ischemic events, while significantly reducing the risk of non-procedure-related bleeding.
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LAAC provides similar overall efficacy and safety compared with medical therapy for stroke prevention in AF but should currently remain reserved for selected patients rather than replacing oral anticoagulation broadly, indicating current evidence remains underpowered and additional randomized trials are needed.
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