Author

Hunain Shahbaz

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Review Open access Oct 2026

Edaravone dexborneol in acute ischaemic stroke: an updated GRADE assessed systematic review and meta-analysis with trial sequential analysis

Despite three decades of neuroprotective failures in acute ischaemic stroke (AIS), edaravone dexborneol (EDB) achieved regulatory approval in China by demonstrating superiority over edaravone monotherapy. The only prior meta-analysis evaluated a single functional endpoint, excluded four subsequent studies including the...

Zaryab Bacha, Hunain Shahbaz, Abbas Khan et al. · The Egyptian Journal of Neur... · 0 citations

Review Sep 2026

Comparing High-Flow Nasal Cannula Therapy and Conventional Oxygen Therapy in Adult Patients Post-Cardiac Surgery: A Systematic Review and Meta-Analysis.

BACKGROUND Cardiac surgery with cardiopulmonary bypass structurally alters respiratory mechanics and carries a substantial risk of postoperative morbidity. Historically, patients have routinely received conventional oxygen therapy (COT) following extubation. High- flow nasal cannula (HCNC) therapy has emerged as an inn...

Muhammad Mustafa Khan, Zaryab Bacha, F. Khan et al. · Journal of Cardiothoracic an... · 0 citations

Review Sep 2026

Efficacy and Safety of Savolitinib Plus Osimertinib in EGFR-Mutant, MET-Aberrant Advanced Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis.

OBJECTIVES NSCLC is the leading cause of cancer-related mortality. While combined therapy including savolitinib and osimertinib appears promising, there exists a lack of comprehensive pooled evidence regarding its anti-oncological activity. The objective of this study is to evaluate the efficacy and safety of combined...

Eshal Amir, M. W. Khan, M. S. Mannan et al. · American Journal of Clinical... · 0 citations

Review Open access Aug 2026

Impact of balloon guide catheter versus conventional guide catheter on technical and clinical outcomes in mechanical thrombectomy for acute ischemic stroke: a systematic review and meta-analysis

Findings do not support a recommendation for or against routine BGC use pending confirmatory randomised evidence, and BGC use during EVT is associated with higher excellent functional recovery and first-pass recanalization.

Hunain Shahbaz, A. A. Malik, Mariya Khan et al. · Egyptian Journal of Neurosur... · 0 citations

Meta-analysis Open access Sep 2026

Efficacy and safety of laparoscopic-guided transversus abdominis plane block versus port-site local anesthetic infiltration in laparoscopic cholecystectomy

LTAP block provides superior early postoperative analgesia compared with port-site local anesthetic infiltration after laparoscopic cholecystectomy, with a modest reduction in hospital stay, although evidence for several secondary outcomes remains limited by heterogeneity and inconclusive trial sequential analysis.

J. Javed, M. Qasim, Zaryab Bacha et al. · Medicine · 0 citations

Review Jul 2026

A systematic review and meta-analysis comparing the clinical outcomes of the Watchman FLX versus Watchman 2.5 device for transcatheter left atrial appendage occlusion in patients with atrial fibrillation.

The Watchman FLX is associated with significantly superior safety and efficacy outcomes relative to the Watchman 2.5 across the principal clinical domains of transcatheter LAAO.

Meerab Ali Khan, Ayesha Muhammad, Hunain Shahbaz et al. · Critical Pathways in Cardiol... · 0 citations