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Particle geometry can alter nanomedicine transport, yet its intrinsic contribution is difficult to define because shape engineering usually changes particle composition or surface chemistry. Here we use sonication to transform compositionally identical SN38 dimeric prodrug nanoassemblies from spheres into rods with asp...
Condensin II shapes interphase genome architecture: species that lack it tend to fold their chromosomes in a Rabl-like, type-I configuration, while species that have it form chromosome territories (type II). In the study that established this, the tardigrade Hypsibius dujardini (now H. exemplaris) was the only species...
A streamlined Azo-enabled one-pot extraction strategy for high-sensitivity top-down analysis of PLN that reduces the required tissue input to 1 mg while preserving analytical performance and establishing a practical strategy for TDP of PLN proteoforms from biopsy-scale and other sample-limited myocardial specimens.
Particle geometry can alter nanomedicine transport, yet its intrinsic contribution is difficult to define because shape engineering usually changes particle composition or surface chemistry. Here we use sonication to transform compositionally identical SN38 dimeric prodrug nanoassemblies from spheres into rods with asp...
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Pre-mRNA splicing is a fundamental process in eukaryotic gene expression. The RNA helicase Prp5 bridges U1 and U2 snRNPs during spliceosome assembly and enhances splicing fidelity. While the N-terminal domain (NTD) of Prp5 is well characterized, the C-terminal domain (CTD) remains underexplored. Here, we show that CTD...
Particle geometry can alter nanomedicine transport, yet its intrinsic contribution is difficult to define because shape engineering usually changes particle composition or surface chemistry. Here we use sonication to transform compositionally identical SN38 dimeric prodrug nanoassemblies from spheres into rods with asp...
Complete analysis pipeline and per-dataset results for the revised version of BIOINF-2026-2348. Includes: (1) unified per-layer probing of ESM-2 650M and SaProt_650M_AF2 on all 63 ProteinGym substitution datasets under three feature arms (masked wild-type, unmasked wild-type, mutant) and four train-test splits (random,...
Particle geometry can alter nanomedicine transport, yet its intrinsic contribution is difficult to define because shape engineering usually changes particle composition or surface chemistry. Here we use sonication to transform compositionally identical SN38 dimeric prodrug nanoassemblies from spheres into rods with asp...
Particle geometry can alter nanomedicine transport, yet its intrinsic contribution is difficult to define because shape engineering usually changes particle composition or surface chemistry. Here we use sonication to transform compositionally identical SN38 dimeric prodrug nanoassemblies from spheres into rods with asp...
Condensin II shapes interphase genome architecture: species that lack it tend to fold their chromosomes in a Rabl-like, type-I configuration, while species that have it form chromosome territories (type II). In the study that established this, the tardigrade Hypsibius dujardini (now H. exemplaris) was the only species...
Particle geometry can alter nanomedicine transport, yet its intrinsic contribution is difficult to define because shape engineering usually changes particle composition or surface chemistry. Here we use sonication to transform compositionally identical SN38 dimeric prodrug nanoassemblies from spheres into rods with asp...
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
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