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1,975 papers
The mainstream approach to splicing therapy today involves synthetic antisense oligonucleotides. ASOs interfere with spliceosomal ribozyme assembly by blocking splice sites or influence protein regulators by blocking or adding their binding sites. ASOs are not compatible with human biology, which limits their efficacy...
U2, U6 and U5 are the components of spliceosomal ribozymes that descend from mobile self-splicing introns. The fragmentation of ancestral introns in eukaryogenesis led to the evolution of the ribozyme assembly in trans using common snRNAs and protein-chaperones. This stepwise process provides opportunities to target di...
Start with the six-page PDF. On 19 September 2026 Edison Scientific and FutureHouse published twelve Millennium Problems for Biology with explicit acceptance criteria. This note takes two of them, Problem 3 (the reverse translatase) and Problem 10 (the protein amplification chain reaction), and proves what the criteria...
Pressure ulcer (PU) typically arises as a chronic cutaneous ulcer stemming from a complex interplay of factors. However, the underlying mechanisms of this condition remain unclear. The aim of this study was to identify inflammatory biomarkers in patients with PU. In this study, PU and normal tissues were collected from...
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BACKGROUND Walnut meal, a major by-product of oil extraction, is rich in protein and bioactive compounds but suffers from poor palatability and low digestibility due to anti-nutritional factors (ANFs) such as phytic acid, tannins, and trypsin inhibitors. Conventional processing methods fail to address these limitations...
There was a positive correlation between TLR-2 expression and inflammatory and disease activity indicators, and TLR-2 expression was considerably higher in RA patients, suggesting that TLR-2 might be a useful biomarker for RA activity and development.
Start with the six-page PDF. On 19 September 2026 Edison Scientific and FutureHouse published twelve Millennium Problems for Biology with explicit acceptance criteria. This note takes two of them, Problem 3 (the reverse translatase) and Problem 10 (the protein amplification chain reaction), and proves what the criteria...
AlphaFold 3 (AF3) has transformed structural bioinformatics through generative diffusion modeling of biomolecular assemblies. However, intrinsically disordered regions (IDRs)—which comprise over 30% of the human proteome and mediate essential cell signaling, oncogenesis, and phase separation—violate the classic thermod...
Genetically proxied smoking was associated with increased risks of uIAs and aSAH, and smoking-related proteins with the risk of unruptured intracranial aneurysms and aneurysmal subarachnoid hemorrhage were assessed.
Geranium (Pelargonium graveolens L.) is an important aromatic plant valued for its essential oil; however, its cultivation in sandy soils is often constrained by poor fertility and limited water-holding capacity. Therefore, this study was conducted to evaluate the effects of Azolla and Moringa extracts on growth, essen...
A variety of insect pests pose a serious threat to global cotton production. Among these, pink bollworm (PBW) and whiteflies are the most devastating, resulting in substantial yield losses and increased pesticide use. Conventional insect-resistance strategies, which primarily rely on single Bacillus thuringiensis (Bt)...
Coarse RNA coordinate representations are widely used, yet the biological information they encode remains unquantified. We introduce FORGE, which converts a seven-atom RNA geometry representation into 935 interpretable descriptors and reports which residue-level annotations this geometry supports. On 4,135 post-2025 RN...
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
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