Repurposing the clinical-stage Bcl-xL BH3 mimetic A-1331852 is identified as a potent PTP1B inhibitor demonstrating a selectivity margin of at least 50-fold over TCPTP, highlighting A-1331852 as a promising starting point for developing PTP1B inhibitors designed to exploit transient, substrate-induced binding states.
Nathaly Vasquez-Martínez, Alejandro Sosa-Peinado, Francisco Cortés-Benítez et al.· Bioorganic & Medicinal Chemi...· 0 citations
This work characterizes the Lm PrsA2 C-tail, demonstrating its contribution to bacterial virulence, chaperone function, and secreted protein activity and highlights its crucial role against cell-wall targeting antibiotics.
Allison Kumar, Charles Agbavor, Francis Alonzo Rd et al.· PLoS Pathogens· 0 citations
Fermented chicken breast is promoted as a healthier alternative to traditional high-fat fermented meat products, yet its quality depends critically on the structural state of myofibrillar protein (MP). To clarify how MP deteriorates during extended natural fermentation, this study established a 150-day fermentation mod...
Yao-Hui Wang, Miao-Yun Li, Jong-Hoon Lee et al.· International Journal of Bio...· 0 citations
This serum proteomic-based prognostic model accurately predicts surgical outcomes for BCLC stage B HCC patients and outperforms clinical stratification by identifying low-risk patients who may benefit from surgery and has the potential to improve survival and quality of life.
Two machine-learning models for predicting ΔΔG0 of TMHs and TMBs using sequence, structure, and energetic features are developed and found that disease-associated mutations were predicted to be destabilizing more frequently than benign mutations.
P. Reddy, A. Kulandaisamy, M. Gromiha· Journal of Molecular Biology· 0 citations
A spatiotemporally coordinated nerve conduit integrating an injectable thermosensitive poly(amino acid) hydrogel with an aligned-random bilayer poly(ε-caprolactone) (PCL) wall provides a potential strategy for peripheral nerve regeneration.
Zhi-Wei Zhao, Jin-Cheng Li, Jian-Feng Liu et al.· Biomaterials Science· 0 citations
Cross-species convergence supports integrated proteomic and lipid indices as sex-informed biomarkers for disease stratification, translation assay development, and therapeutic targeting in obesity and cardiometabolic disease.
Amanda Ifft, Ren-Liang Zhang, Ling Li et al.· Clinical Chemistry· 0 citations
into basal-like and classical states is a critical prognostic determinant, yet clinical implementation remains limited by the cost and turnaround time of transcriptomic sequencing. 1 – 3 Although routine histopathology captures rich morphological features, deep learning models often lack a principled connection to gene...
Alejandro Leyva, Abdul Rehman Akbar, M. K. Niazi· Signal Transduction and Targ...· 0 citations
Auditing sixteen further peptide benchmarks shows the coupling is not confined to this resource: fragment families share a label more often than chance in eleven of fourteen testable datasets, and not in three, so the property is common rather than universal.
Ariful Islam, Md. Faruk Hosen, Md. Abul Basar et al.· bioRxiv· 0 citations
FINDING: Viral capsid architecture is governed by icosahedral symmetry and quasi-equivalence theory, where the triangulation number T = h² + hk + k² (h,k ≥ 0 integers) determines the number of protein subunits (60T) and their arrangement on a spherical lattice. | MATH: T = h² + hk + k²; capsid protein count = 60T; allo...
Andrew Stewart Caldin· Zenodo (CERN European Organi...· 0 citations
Since 1986, replicate lines of the seed beetle Acanthoscelides obtectus have been kept under two experimental evolution regimes: Early (E; lines EI–EIV), where beetles reproduce only during the first two days of adult life, and Late (L; lines LV–LVIII), where egg laying is only possible after day 10. After over 200 gen...
Athanasios Toros, Mats E. Pettersson, Angela P. Fuentes‐Pardo et al.· SciLifeLab Data Repository· 0 citations
Structural genomics is used to find drug targets among the proteins a genome leaves unnamed: a protein with no sequence homologue but a confidently predicted fold looks both novel and tractable. I show that in Plasmodium falciparum this reasoning fails four times before it reaches a target list. Of 1017 confidently mod...
Khan Osman· Zenodo (CERN European Organi...· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
