Side chain assignments are essential for in-depth characterization of proteins. We present here two refined TOCSY experiments based on the use of a variant of “perfect echo” to partially suppress the negative effects arising from homonuclear 13C couplings in the indirect dimension: The iPE-(H)CCH-TOCSY for correlating...
Arnelle Löbbert, Aditya Pokharna, Philipp Rössler et al.· Journal of Biomolecular NMR· 0 citations
A diet low in FODMAP may negatively affect the gut microbiota of some Irritable Bowel Syndrome (IBS) patients, despite alleviating symptoms. This pilot study comprehensively explores the effects of a 3-week ur gut® supplementation on gut microbiota, gut health, dietary intake, sleep, mental health and quality of life (...
Ran Yan, A. Devine, J. Lo et al.· European Journal of Nutritio...· 0 citations
The NMR data confirmed that Lystar5 adopts a classic "three-finger" fold stabilized by six disulfide bonds, providing the first detailed structural and dynamic characterization of an echinoderm TFP.
A. S. Paramonov, M. Shulepko, A. M. Chernikov et al.· Russian journal of bioorgani...· 0 citations
The Generalized Langevin Equation (GLE) is an integro-differential equation of motion for a general observable of a many-body system and is rigorously derived using the projection operator formalism. In the standard derivation, a stationary canonical phase space distribution is used for the projection. Here, we derive...
Salma H. Salem, L. Tepper, Benjamin J. A. Héry et al.· 0 citations
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Proteins possessing the Tubby domain (Tubby-like proteins, TLPs) are widespread in plants and represented by protein families. Although the function of TLPs is frequently associated with plant response to stresses, the mechanisms of their action are largely unknown. The recently demonstrated interaction of Tubic (Nicot...
Grigoriy G. Safronov, Artemii A. Pigidanov, R. A. Galiullina et al.· International Journal of Mol...· 0 citations
Elevated levels of the pro-inflammatory cytokine Interleukin 21 (IL-21) contribute to the progression of autoimmune and inflammatory diseases by binding to its receptor (IL-21R) and activating detrimental signaling pathways in immune cells. Consequently, we developed a recombinant decoy receptor protein designed to com...
Sara Vazifeshenas, Zahra Hajihassan, Seyed Shahriar Arab et al.· Figshare· 0 citations
Complete ammonia-oxidizing (comammox) Nitrospira are recognized as key players in the nitrogen cycle, yet their ecological roles in extreme environments remain poorly understood. Here, we show that comammox Nitrospira occupy distinct ecological niches in Tibetan Plateau thermokarst lakes (pH 7.5–10.2) using stable isot...
Kang Song, Yuren Wang, Lu Li et al.· Nature Communications· 0 citations
Background: Zika virus (ZIKV) and dengue virus (DENV) co-circulate in tropical regions and elicit cross-reactive immunity. However, differential neutralization of closely related ZIKV strains remains unclear. This study characterizes the neutralization profiles of dengue-immune sera against DENV and two Asian-lineage Z...
Jia-Yi Tan, N. Zainal, S. Abubakar et al.· Biomolecules· 0 citations
Elevated levels of the pro-inflammatory cytokine Interleukin 21 (IL-21) contribute to the progression of autoimmune and inflammatory diseases by binding to its receptor (IL-21R) and activating detrimental signaling pathways in immune cells. Consequently, we developed a recombinant decoy receptor protein designed to com...
Sara Vazifeshenas, Zahra Hajihassan, Seyed Shahriar Arab et al.· Figshare· 0 citations
An aptamer’s low mass confines the label-free response to hundredths of a nanometer, where artifacts mimic binding yet yield computable dissociation constants. To define and test a priori criteria distinguishing binding from artifact, 88 computationally designed aptamers against seven human proteins were studied by bio...
E. Ershova, N. Pozdnyakova, A. Egorshina et al.· International Journal of Mol...· 0 citations
Nearly a century after Otto Warburg first described a unique phenomenon whereby tumour cells prefer the inefficient glycolytic pathway for energy generation (Warburg, 1956), the phenomenon has continued to aid researchers in exploring the tumour ecosystem, including tumour initiation, progression and targeting. Further...
Monde Ntwasa, Ekene Emmanuel Nweke, Mandeep Kaur et al.· Frontiers in Immunology· 0 citations
The crystal structure of the Ancient domain of chicken IMPACT (GgIMPACTAncient) is determined, providing the first crystallographic view of a metazoan IMPACT Ancient domain and a structural framework for testing the biochemical function of this evolutionarily conserved module.
Mirai Ido, S. Ito, T. Nishino· Crystals· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
