Integrative and conjugative elements (ICEs) are major drivers of horizontal gene transfer and bacterial genome evolution. Although ICE-encoded regulatory circuits have been extensively characterized, the impact of host physiology on the stability of integrated ICEs remains poorly understood. Here, we identify a host-de...
Liang Bao, T. Kitten, Ping Xu· bioRxiv· 0 citations
Deep-learning models have transformed our ability to predict the phenotypic effects of sequence perturbations. Protein language models (pLMs) score the evolutionary propensity of any amino-acid substitution, emerging as fast and accurate predictors of fitness changes. Inverse-folding (IF) models add structural informat...
Ezequiel A. Galpern, Charles W. J. Pugh, Mafalda Dias et al.· ChemRxiv· 0 citations
The phosphoinositide 3-kinase (PI3K)/3-phosphoinositide-dependent protein kinase-1 (PDK1)/protein kinase B (AKT) signaling axis is dysregulated in breast cancer progression and therapeutic resistance. In this study, an integrated computational workflow was developed to prioritize FDA-approved drugs as potential PDK1-ta...
НА РУССКОМ (RU): Аннотация. Завершающая работа трилогии PANCHONDRIOME 3.5 переходит от макроскопических метафор к квантово-полевому базису живой материи — голограмме Фрёлиха, выводя пространственный инвариант морфогенеза dL = 6.25 мкм на стыке ТГц Бозе-конденсации (0.24 ТГц) и EZ-воды Поллака. Представлено опровержение...
Konstantin D. Pisarenko· Zenodo (CERN European Organi...· 0 citations
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This dataset provides the source-data files underlying the figures and the reagent inventories of the study "Aqueous Hellenia speciosa rhizome extract attenuates hepatic injury in high-fat diet/streptozotocin-induced diabetic rats" (Filfilan & Elbeeh). Included: (1) Figure 6 per-field morphometric source values (steato...
Background: Amazonian biodiversity includes plant resources with potential metabolic activity. Buriti (Mauritia flexuosa) contains monounsaturated fatty acids, carotenoids, and phenolic compounds. Objectives: This study evaluated treatment-associated biochemical and morphological differences after buriti oil or lyophil...
Final reproducibility package aligned with the train-fold-only PCA development analysis, within-benchmark antifungal confirmation, external TAPE remote-homology validation, Supplementary Tables S1-S6 and current Figure 1-3 source data.
renxingye110· Zenodo (CERN European Organi...· 0 citations
Structural analysis and fluorometric evidence indicate that, over evolutionary time, these proteins lost the ability to properly bind GSSG, thereby abolishing hyper-reactivity, and pKa values of their cysteines are scattered across a wide range, resulting in a hierarchical reactivity toward GSSG that may be crucial for...
Unknown authors· Biochemical and Biophysical...· 0 citations
This work probes the structure and function of the orphan toxin-immunity pair Rhs2-SciX, demonstrates the biochemical diversity of Salmonella T6SS effectors, and highlights the conserved T6SS toxicity strategy of binding EF-Tu.
N. Cobo, S. Goyal, David E. Davidson et al.· Journal of Molecular Biology· 0 citations
Intramolecular distances existing between the sheets that define the β-barrel fold of BsCspB have been shown to respond nonuniformly to increasing hydrostatic pressure, suggesting that the three-dimensional structure of native BsCspB is modified such that β-strands depart from each other.
Frédéric Berner, Michael Kovermann· Biophysical Journal· 0 citations
Metabolite abundances represent the ultimate functional outputs of cellular processes and provide a direct link between genotype and phenotype. While the evolutionary dynamics of mRNA and protein abundances have been extensively studied, the evolutionary forces shaping metabolite abundances remain largely unexplored. H...
Hai-Chao Li, Hao-Xuan Liu· Molecular biology and evolut...· 0 citations
Zhang, Xiaoying, Jiajia Wu, Yuchan Zhang, Yuquan Xie, Qi Si, Shadi Li, and Yiwei Han. PPARα activation attenuates right ventricular hypertrophy by regulating myocardial glucose and lipid metabolism in high-altitude pulmonary hypertension in vivo and in vitro. High Alt Med Biol. 00:00-00, 2026.
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Xiao-Ying Zhang, Jia-Jia Wu, Yu-Chan Zhang et al.· High Altitude Medicine & Bio...· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
