The Coherence Maintenance Framework (CMF), established in Papers 1 and 2, demonstrates that threshold-gated regulatory architecture is a universal feature of driven non-linear systems across 29 orders of magnitude in scale. While R_mode = f_pert * tau_relax quantitatively categorizes regulatory dynamics into discrete o...
David Matthews· Zenodo (CERN European Organi...· 0 citations
The protein kinase-like (PKL) superfamily regulates metabolism, biofilm formation, host interactions, and antimicrobial resistance in bacteria, although much of its diversity remains unknown. We used a structure-based pipeline that combined protein structure prediction with structural similarity searches to search 5.1...
Marianna Krysińska, Weronika Śliczniak, Z. Jakubowska et al.· bioRxiv· 0 citations
Short-duration exposure (SDE) of antibiotics is among the major drivers of the emergence of antimicrobial resistance (AMR) among bacterial pathogens. Klebsiella pneumoniae is a critical priority bacterial pathogen and rapidly acquiring MDR/XDR traits even against major antibacterial classes of antibiotics. Since colist...
ABSTRACT Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA) are ESKAPE pathogens that are responsible for severe skin and soft tissue infections (SSTIs), particularly in the elderly and those with immunocompromising conditions. Rising rates of methicillin-resistant S. aureus (MRSA) and carbapenem-resistant PA h...
Suhrid Maiti, T. Lu, Zackary Dietz et al.· Infection and Immunity· 0 citations
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Melanoma is a highly immunogenic malignancy originating from melanocytes and is distinguished by a significantly higher propensity for metastasis compared to other cutaneous cancers (1)(2). This strong immunogenicity is evidenced by dense lymphocytic infiltration within the tumor microenvironment (TME) and an increased...
Chunyan Feng, Yueyue Liu, Xinyue Zhong et al.· Frontiers in Immunology· 0 citations
ABSTRACT Microplastics (MPs) and nanoplastics (NPs) have emerged as ubiquitous environmental contaminants with profound implications for human neurological health. Recent landmark findings confirm the bioaccumulation of MPs/NPs in human brain tissue—with concentrations reaching 4917 μg/g in 2024 autopsy samples and up...
Alfi Sophian, Asmariani, Erika Ismayani· Journal of biochemical and m...· 0 citations
We propose that a single information-theoretic operation — the many-to-one map on a physical system's state space, followed by inaccessibility of the discarded alternatives — is the missing universal principle underlying defmiteness, selection, irreversibility, and the emergence of classical structure across every scal...
Scott G J Devine· Zenodo (CERN European Organi...· 0 citations
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) poses a significant public health threat, with a fatality rate of 37% and no approved therapeutics (World Health Organization, 2026). Non-structural protein 10 (nsp10) is an essential cofactor that activates both the nsp14 3’-5’ exoribonuclease (ExoN) activity req...
D. Dong, F. Kozielski, Christopher A. Waudby· bioRxiv· 0 citations
Background/Objectives: The very low-density lipoprotein receptor (VLDLR) mediates VLDL uptake in peripheral tissues. This study investigated sex differences in hepatic VLDLR response to protein restriction and its relationship with hepatic lipid accumulation. Methods: Male and female wild-type (WT) and Vldlr knockout (...
Statistical analysis of protein crystallization outcomes in the final TargetTrack release (1 July 2017; 52,307 purified structural-genomics targets across 17 centres, within-centre models). Finding: at equal net-charge magnitude, positively charged proteins are recorded as crystallized less often than negatively charge...
LI-CHI CHANG· Zenodo (CERN European Organi...· 0 citations
Introduction Anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (ANCA-GN) and immunoglobulin G4-related disease (IgG4-RD) are rare autoimmune conditions. Although case reports suggest potential clinical and pathophysiological overlaps, the cross-tissue transcriptional associations between these diseases...
Fluorescent molecular probes for selective and real-time detection of human serum albumin (HSA) protein in urine and blood have important applications in clinical diagnostics for various diseases. The majority of known fluorescent HSA probes give emission in the blue-green spectral region where biological autofluoresce...
Brian Corbin, Jessica Mason, Paityn Houglan et al.· Biosensors· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
