A previously undescribed polysaccharide was isolated from the edible mushroom Russula adusta. Structural analysis showed that Russula adusta polysaccharide (RA‑P) has a molecular mass of 20,576 Da and main chain consists of (1→4,6)-Glcp, (1→4)-D-Glcp, (1→4)-D-Galp and (1→6)-Galp remnants, with side chain →1)-Galp and a...
Shu-Rong He, Xin-Lin Li, Jie Tang et al.· Chiang Mai Journal of Scienc...· 0 citations
Plasma betaine and its downstream metabolites, N,N-dimethylglycine, sarcosine and serine, and its downstream metabolites, N,N-dimethylglycine, sarcosine and serine, were greater in BET than in CTRL, suggesting a potential sparing effect.
Amelia M. Huebsch, J. Pezzali· Journal of Animal Science· 0 citations
Feed efficiency (FE) is a complex trait with major implications for the sustainability and profitability of dairy production; however, the potential association of the milk-associated microbiota with this phenotype remains largely unexplored. Additionally, milk somatic cells (MSC) provide a minimally invasive and eas...
Á. Cánovas, Guilherme Henrique Gebim Polizel, Le-Luo Guan et al.· Journal of Animal Science· 0 citations
Recombinant proteins are the workhorse of modern biochemical research, yet their use
in vitro
is routinely questioned on grounds of physiological relevance. Here we provide a structured guide to the strengths and limitations of recombinant protein studies, framed within the broader contrast between systemic (top-do...
D. Dell'Orco, Karl-W Koch· Frontiers in Molecular Biosc...· 0 citations
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Post-traumatic stress disorder (PTSD) is associated with immune and autonomic disturbances, but molecular programs linking PTSD-related blood transcriptional signals with autonomic–cardiac biology remain incompletely characterized. The public Gene Expression Omnibus (GEO) cohorts analyzed here did not directly measure...
Yi-Han Guo, Dong-Dong Shi, Lan-Ying Liu et al.· International Journal of Mol...· 0 citations
In cases of subjects with ITP, there was a marked reduction in the counts and indices of platelets and expression of the PTPN22 gene, and other indicators, including ANA, IL-37, IL-40, PA-Ab, rs2488457, and rs1395448650 were not significantly linked to ITP.
Sarah Nabeel Lamam, S. R. Ibraheem· Iraqi Journal of Hematology· 0 citations
Self-supervised pre-training has become the dominant paradigm in single-cell and protein modelling, yet its value for microbiome-based disease classification remains untested under evaluation protocols that control for study-level confounding. Public metagenomic collections aggregate hundreds of independently conducted...
Khaled Sayed· Zenodo (CERN European Organi...· 0 citations
Pancreatic ductal adenocarcinoma (PDAC) accumulates vast amounts of hyaluronic acid (HA), generating a rigid, high-pressure stroma that blocks drug delivery and infiltration. Although hyaluronidase (HAase) can dismantle this barrier, systemic administration of HAase depletes HA from healthy tissues and causes dose-limi...
Background: Cytokine Release Syndrome (CRS) is a major driver of acute organ failure in critical care settings, affecting approximately 49 million people and killing approximately 11 million people annually. Targeting multiple dysregulated feedback loops via single-molecule polypharmacology offers a promising strategy...
Leo Meng, Valentina L. Kouznetsova, Santosh Kesari et al.· ChemRxiv· 0 citations
The hydrophobic effect is one of the central organizing principles of molecular biology, underpinning protein folding, molecular recognition, membrane self-assembly and many forms of biomolecular recognition. Contemporary statistical-mechanical frameworks explain much of its thermodynamics, including the dependence of...
Dataset Title: Refined Coordinate Structures and Pocket Analyses for Neurodegenerative Disease Targets (v3.0) Overview: Fully quality-controlled 3D structural models, geometric pocket analyses, DiffDock docking enrichment, and NIH NCBI cross-validated target records for 6 therapeutic targets in this disease area: APOE4...
James Paul Trageser· Zenodo (CERN European Organi...· 0 citations
The breast cancer resistance protein (BCRP;
ABCG2
) is an efflux transporter that affects drug pharmacokinetics, contributes to multidrug resistance, and can cause drug-drug interactions (DDIs). Predicting whether a compound interacts with BCRP can aid in the development of adjuvant anti-cancer drugs and help ant...
Souvik Dey, P. Lu, Anders Wallqvist et al.· Scientific Reports· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
