It is indicated that chlorogenic acid influences testicular oxidative status and ferroptosis-related gene responses under acrylamide exposure, supporting its potential relevance as a dietary component for acrylamide-associated reproductive oxidative stress.
Hasan Hüseyin Keçeli, A. Yakan, Hüseyin Özkan· Ankara Üniversitesi Veterine...· 0 citations
Dysphagia-adapted fluidized meat products alter the protein matrix structure and may impair digestibility. This work evaluated the digestive and nutritional properties of carboxymethyl cellulose (CMC)-modified myofibrillar protein (MP) thickened fluids across three matrices: liquid solution (MP), semisolid state (MP/CM...
Jiale Chai, Jing-Jie Wang, Yue Wang et al.· Journal of Agricultural and...· 0 citations
Higher order protein structural predictions suggested that the putative epistatic interactions among E180V, G184V, and G252V, D253G may be associated with S protein folding and structural stability.
M. Jogi, Sristy Shikha, Pushpendra Singh et al.· Frontiers in Immunology· 0 citations
Fluorescence-based immunoassays are widely used for sensitive and specific biomarker detection; however, further improvements in sensitivity remain desirable for detecting low-abundance analytes without increasing assay complexity. In this work, we present a proof-of-concept demonstration of guided electrokinetic assem...
Tuo Zhou, Alfonso Shin, L. Kulinsky· Italian National Conference...· 0 citations
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In vivo evidence is provided for choroid plexus dysfunction in a maternally inherited disorder with convergent evidence supporting a mitochondrial aetiology, associated with reduced CSF production and impaired blood–CSF barrier transport, substantially altering biomarker profiles in the absence of cortical atrophy or b...
P. Selnes, J. Jarholm, Antón Vila-Sanjurjo et al.· Fluids and Barriers of the C...· 0 citations
Background Breast cancer remains one of the leading causes of cancer-related mortality among women worldwide, necessitating the development of safer and more targeted therapeutic strategies. This study computationally extends our previous experimental investigation of a peptide derived from Lacticaseibacillus casei by...
G. R. Shree Kumari, M. Vaithilingam· Frontiers in Bioinformatics· 0 citations
This work investigates how protein folding landscapes are altered inside condensates, using the protein α-helix as a model folded domain and develops a chemically specific, residue-resolution model for quantification of α-helical folding and applies it to characterize diverse helices within condensates of varying physi...
Nathaniel Hess, Jerelle A. Joseph· Journal of the American Chem...· 1 citation
The quaternary ammonium strategy represents an effective approach to developing water-soluble PD-1/PD-L1 inhibitors with dual immunomodulatory and antiangiogenic functions.
Jianwei Xu, Pan Yang, Xixiang Yang et al.· Journal of Medicinal Chemist...· 0 citations
These findings establish NABi as a promising therapeutic candidate for SOD1G93A-associated familial ALS, demonstrating its capacity to selectively target pathological protein conformations while preserving normal cellular function.
Min-Kyung Nam, Y. Oh, Yemi Choi et al.· ACS Chemical Neuroscience· 0 citations
A DNA molecular robot that converts tumor microenvironment and near-infrared stimuli into integrin-mediated mechanical forces, generating microtubule-targeting activity without drugs is developed, providing a nonpharmacological strategy for dual-functional implants with synergistic antitumor and osteogenic activities.
Results show that HsbA proteins in Mucor lusitanicus function as regulators that couple fungal surface remodeling with developmental transitions, thereby coordinating environmental adaptation and host–pathogen interactions.
Anna Molnár, Amanda Grace Vaz, M. Homa et al.· Frontiers in Cellular and In...· 0 citations
SERPINA3 is therefore an exploratory adjunctive serum biomarker candidate rather than a stand-alone diagnostic test; prospective external validation in clinically representative cohorts is required.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
