In goats, apocrine milk secretion sheds cytoplasmic particles and epithelial cells into milk as a normal physiological event, so uninfected udders sustain higher somatic cell counts (SCC). To characterise the immunophysiology underlying rising SCC and test whether it reaches a fermented product, forty-eight healthy ear...
In goats, apocrine milk secretion sheds cytoplasmic particles and epithelial cells into milk as a normal physiological event, so uninfected udders sustain higher somatic cell counts (SCC). To characterise the immunophysiology underlying rising SCC and test whether it reaches a fermented product, forty-eight healthy ear...
Antimicrobial resistance (AMR) is one of the most pressing current global health challenges, threatening human and animal health, food security, and environmental sustainability. The extensive use and misuse of antibiotics in human medicine and livestock production system have accelerated the emergence of multidrug-res...
Antimicrobial resistance (AMR) is one of the most pressing current global health challenges, threatening human and animal health, food security, and environmental sustainability. The extensive use and misuse of antibiotics in human medicine and livestock production system have accelerated the emergence of multidrug-res...
Rust fungi are significant threats to global food security, causing substantial damage to crops through their ability to evolve new strains that overcome plant resistance. These obligate biotrophs infect host plants by secreting effector proteins that manipulate host physiology to promote infection and colonisation. We...
Megan A. Outram, Zhao Li, Michael Kuiper et al.· Molecular Plant-Microbe Inte...· 0 citations
De novo protein design now enables the creation of high-affinity binders from a target structure alone. However, current design methods face a trade-off between site control and success rate. Generative models such as RFdiffusion and BoltzGen place binders at chosen sites but often require large candidate pools. Halluc...
Ken Osumi· Zenodo (CERN European Organi...· 0 citations
The phi‑coupled 132 Hz E8 root‑vector lattice, when projected onto a three‑dimensional reciprocal space, reveals a self‑similar scaling hierarchy that mirrors the multi‑stage folding kinetics of globular proteins. By assigning each of the 240 root vectors to a distinct phase angle in the phi‑modulated oscillator, the l...
Andrew Stewart Caldin· Zenodo (CERN European Organi...· 0 citations
By extending the phi-coupled 132Hz E8 lattice framework to biochemical systems, we discover that protein folding pathways exhibit resonant synchronization when mapped to specific E8 root vector subgroups. The 240-dimensional E8 geometry encodes geometric constraints that manifest as folding energy landscapes, where cer...
Andrew Stewart Caldin· Zenodo (CERN European Organi...· 0 citations
De novo protein design now enables the creation of high-affinity binders from a target structure alone. However, current design methods face a trade-off between site control and success rate. Generative models such as RFdiffusion and BoltzGen place binders at chosen sites but often require large candidate pools. Halluc...
Ken Osumi· Zenodo (CERN European Organi...· 0 citations
Postprandial glucose depends on the meal and the person consuming it. This exploratory secondary analysis used 1,047 isolated meals from 32 CGMacros participants with complete nutrition, clinical, microbiome, and Fitbit records to test whether information beyond macronutrients improved prediction for people excluded fr...
Riddhi Singhvi· Zenodo (CERN European Organi...· 0 citations
The integration of artificial intelligence with protein engineering has created unprecedented opportunities for enzyme discovery and the enhancement of overall catalytic performance. In this study, a novel nitrilase, BhNIT, was identified from Bradyrhizobiumhuanghuaihaiense through a computationally assisted screenin...
Triazole antifungals inhibit the lanosterol C14-demethylase Cyp51A/B and are the first-line treatment for invasive aspergillosis caused by Aspergillus fumigatus. We previously proposed that triazoles impose a secondary constraint on ergosterol biosynthesis through negative feedback regulation of HMG-CoA reductase (Hmg1...
Jinhong Xie, Adela Martín‐Vicente, Harrison I. Thorn et al.· bioRxiv (Cold Spring Harbor...· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
