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1,870 papers
ELMS (Evidence-based LLM-guided Monte Carlo Search), an evaluator-in-the-loop search framework for motif scaffolding that turns such evaluator feedback into targeted design actions, is introduced.
It is demonstrated that PDI(a)-mediated cis-fusion enables high-yield production of structurally native-like and functionally competent HSA in the bacterial cytosol and provides a practical platform for producing complex disulfide-rich proteins in E. coli.
Rapid and scalable protein binder discovery platforms are essential for accelerating therapeutic and diagnostic development. Click display is a cell-free protein display technology that covalently links nascent proteins to their encoding cDNA in a one-pot reaction within 2 hours, enabling rapid in vitro selection. Alth...
A plasmid-based reverse genetics system was established for red-spotted grouper nervous necrosis virus, and codon mutations on B1 and B2 proteins were introduced, and all mutated codons had been reverted to the original sequence.
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It is shown that pIgR-targeted bispecific antibodies rapidly deplete from serum, while enriching 5-10-fold in bronchoalveolar lavage fluid compared to normal IgG antibodies, which support the use of anti-pIgR bispecific antibodies to treat diseases requiring targeting in mucosal areas.
Preliminary evidence is provided for establishing an efficient transient expression platform while offering initial mechanistic insights into how iron ions influence PEI-mediated transfection via complex morphology and transcriptional regulation.
Selectin plays a crucial role in the form of a key molecular mediators for feto-maternal communication during pregnancy. Particularly, P-selectin is an adhesion molecule expressed predominantly on activated endothelial cells and platelets is also widely recognized for its role in leukocyte recruitment during inflammati...
Transportation exposes sheep to physical, physiological, and psychological stressors—such as loading, vehicle movement, confinement, social mixing, feed/water deprivation, and thermal extremes. These factors disrupt homeostasis, triggering the sympathetic–adrenomedullary system and the hypothalamic–pituitary–adrenal ax...
Transportation exposes sheep to physical, physiological, and psychological stressors—such as loading, vehicle movement, confinement, social mixing, feed/water deprivation, and thermal extremes. These factors disrupt homeostasis, triggering the sympathetic–adrenomedullary system and the hypothalamic–pituitary–adrenal ax...
Selectin plays a crucial role in the form of a key molecular mediators for feto-maternal communication during pregnancy. Particularly, P-selectin is an adhesion molecule expressed predominantly on activated endothelial cells and platelets is also widely recognized for its role in leukocyte recruitment during inflammati...
INTRODUCTION: Bovine (Bos taurus and Bos indicus) and buffalo (Bubalus bubalis) are economically important livestock species and major contributors to milk and meat production. Assisted reproductive technologies, particularly in vitro embryo production (IVEP), provide important opportunities for the rapid multiplicatio...
INTRODUCTION: Bovine (Bos taurus and Bos indicus) and buffalo (Bubalus bubalis) are economically important livestock species and major contributors to milk and meat production. Assisted reproductive technologies, particularly in vitro embryo production (IVEP), provide important opportunities for the rapid multiplicatio...
Proof of concept for watermarking AI-generated proteins while preserving biological function.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Scientists are using AlphaFold to strengthen a photosynthesis enzyme for resilient, heat-tolerant crops.
Explore how AlphaFold has accelerated science and fueled a global wave of biological discovery.
AlphaFold has revealed the structure of a key protein behind heart disease
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