A CRISPR/Cas9 genome editing workflow is established for U. unicinctus based on an optimized microinjection procedure, providing a technical framework for functional genomics in echiurans and facilitating future studies of developmental mechanisms and molecular breeding in this species.
Kai Wang, Jiao Chen, Shumiao Bai et al.· Marine Biotechnology· 0 citations
In general, CRISPR/Cas9-based engineering is a promising way of developing the next generation of precision cancer immunotherapy and is likely to be improved further in future through advancements in genome editing technology, delivery methods, and synthetic biology.
Meng-Ying Liu· International Journal of Bio...· 0 citations
Clinical guidelines, including China-specific recommendations, support the use of PCSK9 inhibitors to lower LDL-C and further reduce CV risk for patients with very-high-risk or high-risk ASCVD.
Yu-Jie Fang· International Journal of Bio...· 0 citations
Overall, CRISPR-Cas9 represents a vital platform for future pharmacological innovation, but its broad clinical use may require further validation of safety, efficacy, durability, and accessibility.
This review highlights how plant defense signaling and transcriptional regulation against aphids can be harnessed to develop sustainable and novel pest management solutions.
V. Patil, Rizwana Rehsawla, Apurba K. Barman· Stress Biology· 0 citations
Background: Hepatocellular carcinoma (HCC) is the predominant histological subtype of primary liver cancer, and many patients with unresectable disease require systemic therapy. This narrative review asks how current systemic regimens should be selected and sequenced, how oncogenic pathways inform resistance and biomar...
While multi-agent LLM pipelines show real promise for legacy code specifically, since their capacity for autonomous context reconstruction and iterative, feedback-driven refinement directly addresses the sparse documentation and thin test coverage that define legacy environments, the literature to date has been validat...
Harsh Verma· International Journal of Sci...· 0 citations
The findings suggest that AI-powered anomaly detection significantly strengthens observability and security in cloud-based applications, enabling proactive threat mitigation and operational optimization in increasingly complex distributed environments.
Harsh Verma· International Journal of Sci...· 1 citation
It is demonstrated that BcNCED3 positively regulates thermotolerance in non-heading Chinese cabbage and provide a genetic resource for heat-tolerance breeding.
Wen-Jun Lu, Chang-Wei Zhang, Zhao-Kun Liu et al.· Plants· 0 citations
The results indicate that GmSHMT05 sustains overall soybean growth and development in the absence of GmSHMT08, however, GmSHMT08’s gain-of-function in SCN resistance negatively influences pod and root growth, highlighting a potential trade-off between soybean defense and development that may impact yield.
Vinavi A. Gamage, Luckio F. Owuocha, Feng Lin et al.· Frontiers in Plant Science· 0 citations
These agents have expanded treatment options for patients with familial dyslipidaemia, severe hypertriglyceridaemia, and persistent residual cardiovascular risk while paving the way for precision medicine.
Aryan Arora· Beyond the Pill – The Future...· 0 citations
A comparative model explaining when and why subventral and dorsal glands exchange, retain, or alternate their functions across contrasting parasitic lifestyles across contrasting parasitic lifestyles is explained.
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