This archive contains the frozen R analysis code, analysis-ready public-data derivatives, patient-level cohort audits, numerical result tables, figure-generation scripts, editable figure files, execution logs, and session information supporting the manuscript “Reassessment of a fixed five-gene inflammatory score in cer...
Xundian Liu, Xiuying Jiang, Wende Zheng et al.· Zenodo (CERN European Organi...· 0 citations
ABSTRACT During early embryogenesis, the sea lamprey ( Petromyzon marinus ) undergoes a dramatic form of genome reprogramming wherein specific chromosomes are selectively eliminated from somatic progenitor cells. These programmatic elimination events effectively silence all genes on these chromosomes in all somatic cel...
Kaan Ihsan I Eskut, Claire Scott, Cody Saraceno et al.· BMC Genomics· 0 citations
Activity-normalized prime editing provides a scalable framework for LDLR variant classification that substantially expands the proportion of variants with evidence for genetic diagnosis and reveals novel biology with therapeutic relevance.
P. Zhou, Minja Velimirovic, Tian Yu et al.· Circulation· 0 citations
that govern them (Hanusch et al., 2026;Ninkuu et al., 2022;Tohge et al., 2018). Recent studies compiled in this special issue collectively demonstrate that plant chemodiversity is driven by intricate coordination between regulatory networks, metabolic pathways, and environmental signals. These studies, ranging from mol...
Vincent Ninkuu, Oluwaseun Olayemi Aluko, Xiupeng Mei et al.· Frontiers in Plant Science· 0 citations
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Scientific exploration is a relay race across generations. From Darwin's observations on plant movement and adaptation, to Mendel's elucidation of fundamental genetic principles using peas, to the modern molecular dissection of plant stress response mechanisms, every advance has depended not only on the strategic visio...
Enhancer editing is widely proposed as a strategy to modulate gene dosage therapeutically. EKLF/KLF1, a master erythroid transcription factor, is an attractive target because haploinsufficiency is benign and associated with hereditary persistence of fetal hemoglobin (HPFH). Here we test whether enhancer disruption can...
A. Planutis, Sanjana Pillay, Babu Mia et al.· Communications Biology· 0 citations
BACKGROUND
Chronic kidney disease (CKD) is characterized by proximal tubule (PT) stress, oxidative injury, and metabolic dysfunction. Human kidney single-nucleus RNA-sequencing (snRNA-seq) identified enrichment of ubiquitin-dependent protein catabolic processes in injured PT cells, suggesting activation of the ubiquiti...
Turgay Saritas, Lu Chen, Sadaf Ijaz et al.· Nephrology, Dialysis and Tra...· 0 citations
The present investigation reports the isolation, cloning and sequence-level validation of OsbHLH024 from the salt-tolerant indica cultivar Ratnagiri-8, which constitutes a genomic resource for future comparative and functional characterisation of OsbHLH024 in salinity tolerance.
V. Shrikaran, S. Sawardekar, S. S. Sawant et al.· Journal of Advances in Biolo...· 0 citations
Genome-wide association study (GWAS) analyses have identified numerous loci associated with economic traits in cattle. Many of these loci reside in noncoding regions, and the regulatory mechanisms through which they influence complex traits remain poorly understood. Here, we integrated 657 RNA-seq libraries from 275 Hu...
Shiyuan Qiu, Li-Li Du, Bo-Yu Zhang et al.· Genomics, Proteomics & Bioin...· 0 citations
This review summarizes molecular regulatory dynamics throughout the full-life-cycle development of yak testes, highlighting core molecular networks governing spermatogonial stem-cell self-renewal, meiotic initiation, and sperm morphogenesis and further integrates the modulatory roles of the testicular microenvironment...
Qing-Qiang Yin, Xin-Xing Zheng, Xing-Dong Wang et al.· Animals· 0 citations
Eggplant, a key strategic horticultural crop within the Solanaceae family, serves as a crucial source of micronutrients, bioactive phytochemicals, and functional foods significantly contributing to food security and sustainable agriculture. Its wide agro-climatic adaptability, economic importance, and versatile culinar...
T. Chandra, Sarika Jaiswal, K. Gaurav et al.· Discover Plants· 0 citations
Exploring how generative AI could make machine vision more accessible to businesses. The post GenEye in a Box: Making Machine Vision Something You Can Just Ask For appeared first on GPT-Lab.
