Opisthopappus is a perennial herb endemic to cliff habitats of the Taihang Mountains and represents a wild germplasm resource for stress-resistance research on Asteraceae industrial crops. However, its mitochondrial genomic architecture and evolutionary patterns remain largely unexplored. Here, the complete mitochondri...
Li Liu, Haoyuan Dan, Bingui Ma et al.· Industrial Crops and Product...· 0 citations
Heavy metal (HM) contamination has become a critical threat to the agro-environment, impairing soil fertility, reducing crop productivity, and disrupting ecological balance. It often displays stunted growth, chlorosis, root rot, and ultimately death of plants in severe cases. Due to increased anthropogenic activities,...
A multiplex prime-editing platform is developed that converts commonly used immunosuppressive drugs into tools for in vivo control of T-cell therapies via defined, pathway-specific drug resistance, enabling selective in vivo modulation in settings where immunosuppression cannot be withdrawn.
E. Bandala-Sanchez, Emma V. Petley, K. Ramsay et al.· Blood· 0 citations
The spectrum of genetic lesions that result in activation of NF‑κB in mature B‑cell malignancies is expanded and highlights the incomplete understanding of NF‑κB drivers in mature B‑cell malignancies.
E. Li, L. Heitink, E. Bandala-Sanchez et al.· Blood· 0 citations
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A critical synthesis of recent advances in pigment regulation is presented, moving beyond descriptive gene lists to examine the mechanistic underpinnings of pigment regulation and provides a foundation for rational manipulation of fruit coloration and nutritional quality.
Tyrosine sulfation is a post-translational modification that has been reported to occur infrequently on recombinant monoclonal antibodies (mAbs). We recently demonstrated that tyrosine sulfation occurred on a bispecific antibody (bsAb) produced in Chinese hamster ovary (CHO) cells, using a multi-enzymatic approach in c...
Jacqualyn J. Schulman, Rachel Egan, Lakshmi Kandari et al.· Biotechnology Journal· 0 citations
Abstract Background MiT/TFE-rearranged, translocation renal cell carcinoma (tRCC) is characterized by gene fusions involving TFE3 or TFEB, and is a rare, aggressive non-ccRCC, often occurring in children and with few biomarkers or targeted therapy options. TFE3 is the most commonly translocated gene with ASPSCR1, PRCC...
K. Asrani, Juhyung Woo, Thiago Vidotto et al.· The Oncologist· 0 citations
ADAR2-mediated A-to-I editing confers an oncogenic role on miR-376a-3p by shifting its target from KPNA4 to HOXD10, thereby facilitating PTC tumorigenesis through enhanced glycolysis.
This article presents a narrative review of CRISPR and the Editing of the Genome in the context of Biology. The literature on this topic has expanded substantially over recent decades, yet it remains fragmented across subfields, methods, and national research traditions. Drawing on an interpretive synthesis of represen...
Zen Revista, 10 BIOLOGY· Zenodo (CERN European Organi...· 0 citations
Maize (Zea mays L.) is one of the most important cereal crops worldwide, playing a fundamental role in food security, animal nutrition, and industrial production. Among the bacterial diseases affecting maize, bacterial stripe caused by Acidovorax avenae subsp. avenae has emerged as a significant phytosanitary concern d...
E. Leão, João Pedro Almeida Lima, Marcos Levi Costa Barbosa et al.· Cerrado: Agricultural and Bi...· 0 citations
This study explores the diverse applications of CRISPR, highlighting its role in treating genetic disorders such as sickle cell anemia and Duchenne muscular dystrophy, advancing cancer immunotherapies, and developing CRISPR-based antiviral therapies for HIV and COVID-19.
B. Aloufi· Journal of Pure and Applied...· 0 citations
Meeting the increasing demand for safe, nutritious, and climate-resilient food requires innovative strategies to enhance vegetable productivity and quality while overcoming the limitations of conventional breeding. Vegetables are vital sources of essential nutrients, vitamins, minerals, and bioactive compounds; however...
Muhammad Mohsin Kaleem, Muhammad Ahtasham Mushtaq, Shariq Mahmood Alam et al.· Current Plant Biology· 0 citations
Exploring how generative AI could make machine vision more accessible to businesses. The post GenEye in a Box: Making Machine Vision Something You Can Just Ask For appeared first on GPT-Lab.
