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1,397 papers
Ultrasound-CRISPR technologies are elaborates potential as a powerful tool that enables targeted, and image-guided genetic interventions, capable of advancing the outcomes of gene therapy as a widespread clinical practice.
Persistent infection with high-risk human papillomaviruses (hrHPVs) is a primary driver of cervical carcinogenesis, with the viral oncogenes E6 and E7 playing pivotal roles. Conventional nuclease-based gene-editing strategies are limited by genome-wide off-target effects and genomic perturbations associated with double...
A comprehensive genome-wide analysis identified 19 serine protease-like DEG family proteins in potato, revealing their structural diversity, domain architecture, and regulatory potential and highlighting the functional versatility of DEG proteases in potato development and stress adaptation.
This work presents a variant-agnostic approach to rescue haploinsufficiency by mapping and rationally redesigning the MYBPC3 promoter and identifies synergistic sequence edits that drive robust increases in MYBPC3 expression.
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Mobile genetic elements drive genome evolution and horizontal gene transfer, yet the mechanisms underlying the mobility of many eukaryotic elements remain poorly understood. Here we show that Starships, a recently discovered class of giant transposable elements in fungi, mobilise via an extrachromosomal circular interm...
This review presents the stem cell technologies applied in tissue engineering, regenerative medicine, or organ transplantation. It describes how certain types of stem cells are different in terms of their characteristics, the methods of their culture isolation, gene editing, and three-dimensional organoid construction....
Cancer remains a major cause of global mortality, while late-stage diagnosis and therapeutic resistance highlight the need for individualized strategies. Nanotheranostics has emerged as a promising paradigm by integrating cancer diagnosis and treatment within multifunctional nanosystems. However, most current approache...
This review examines the historical development of CRISPR technology from its initial discovery as a bacterial immune mechanism to its transformation into a revolutionary genome editing tool. The narrative traces the key scientific milestones that led to the adaptation of CRISPR-Cas9 as a precise molecular scissor capa...
This review systematically synthesizes the liver's multifaceted roles in teleost salinity adaptation, including glucolipid metabolic reprogramming, osmosensory signaling, cytoskeleal remodeling, and hormonal coordination.
This review examines the historical development of CRISPR technology from its initial discovery as a bacterial immune mechanism to its transformation into a revolutionary genome editing tool. The narrative traces the key scientific milestones that led to the adaptation of CRISPR-Cas9 as a precise molecular scissor capa...
# Data and code for "Causal screening of the plasma proteome and skin transcriptome in keloid: six candidate loci and the limits of Mendelian randomisation for target nomination" Version v1.0. This archive accompanies the manuscript above (Li Zhifeng, Li Jingyu; Zhejiang Provincial People's Hospital). It contains the a...
It is argued that improvements in editing efficiency alone will be insufficient; clinical success will require the simultaneous achievement of tumor‐selective delivery, genomic integrity, and acceptable long‐term safety, and the continued development of novel approaches should be promoted to realize the full potential...
GPT-Lab
· gpt-lab.eu
Oct 8, 2026
Exploring how generative AI could make machine vision more accessible to businesses. The post GenEye in a Box: Making Machine Vision Something You Can Just Ask For appeared first on GPT-Lab.
A Blog post by Ai2 on Hugging Face
A Blog post by ServiceNow-AI on Hugging Face
“InstructMesh” can generate designs for everyday objects that are easy to edit and fabricate for both experts and newcomers to 3D modeling.
Proof of concept for watermarking AI-generated proteins while preserving biological function.
Algorithms & Theory
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