gene editing

Introgressive hybridization fuels local adaptation in oakleaf butterflies

Hybridization may have multiple impacts on speciation and adaptation. Yet the evidence of adaptive introgression events that have historically occurred between nonradiating or established species is still lacking. The oakleaf butterflies in the genus Kallima include multiple sympatric and incipient species with a kno...

The epigenetic landscape of plant defense: Unlocking nature's toolkit for new plant protection

This review proposes epigenetic editing as a versatile and sustainable tool for unlocking the plant immune repertoire and developing disease‐resistant plants, offering a promising alternative that addresses several limitations of conventional genetic modification.

Graph-Immune-Optimization (GIO): An Integrated AI-Driven Framework for Simulation-Guided Design of CAR-T/NK Cell Therapy and CRISPR Gene Therapy in Cancer Immunotherapy

Precision nanomedicine for chemotherapy and gene therapy

Precision nanomedicine has emerged as a transformative approach in chemotherapy and gene therapy, leveraging advances in nanotechnology, materials science, and molecular biology to enhance drug delivery efficacy while minimizing off-target toxicity. Conventional chemotherapy faces challenges such as systemic toxicity,...

Genetic prioritization and donor-resolved microglial expression of GRN in Alzheimer's disease: reproducibility data and code

This archive (v1.0.0) accompanies the manuscript "Genetic prioritization and donor-resolved microglial expression of GRN in Alzheimer's disease". It contains the reproducibility bundle: analysis code with identified intermediate inputs, complete reported result families for the transcriptome-wide genetic screen (9,561-...

Genetic prioritization and donor-resolved microglial expression of GRN in Alzheimer's disease: reproducibility data and code

This archive (v1.0.0) accompanies the manuscript "Genetic prioritization and donor-resolved microglial expression of GRN in Alzheimer's disease". It contains the reproducibility bundle: analysis code with identified intermediate inputs, complete reported result families for the transcriptome-wide genetic screen (9,561-...

Resistance gene analogue identification and comparative genomic analysis of two Brassica carinata genomes

This study systematically identify and characterise RGAs in two newly assembled B. carinata genomes, revealing their genomic organisation, duplication patterns, and evolutionary relationships, thereby offering valuable genetic resources for developing disease-resistant and resilient cultivars of this emerging oilseed c...

《Nanomedicine & Biointerfaces at the Limit: Precision Delivery, Diagnostics, Sequencing, Regeneration, and Safe Human Interfaces》 is a flagship-scale research volume exploring what happens when nanoscale engineering begins to interact directly with living systems.

《Nanomedicine & Biointerfaces at the Limit: Precision Delivery, Diagnostics, Sequencing, Regeneration, and Safe Human Interfaces》 is a flagship-scale research volume exploring what happens when nanoscale engineering begins to interact directly with living systems. The central question is not simply: Can nanoparticles...

《Nanomedicine & Biointerfaces at the Limit: Precision Delivery, Diagnostics, Sequencing, Regeneration, and Safe Human Interfaces》 is a flagship-scale research volume exploring what happens when nanoscale engineering begins to interact directly with living systems.

《Nanomedicine & Biointerfaces at the Limit: Precision Delivery, Diagnostics, Sequencing, Regeneration, and Safe Human Interfaces》 is a flagship-scale research volume exploring what happens when nanoscale engineering begins to interact directly with living systems. The central question is not simply: Can nanoparticles...

Toward Iron-Biofortified Rice: Integrating BRUTUS-Family Regulation and Iron Chaperone Biology

The classical rice framework that underpins biofortification, including Strategy II-type uptake, nicotianamine and deoxymugineic acid chemistry, long-distance transport, grain loading, ferritin buffering, and vacuolar sequestration are summarized.

Engineering a compact CgCas12n platform for efficient genome and base editing in mammalian cells.

An enhanced CgCas12n system (eCgCas12n) is established that enables efficient mammalian genome editing and provides an efficient genome- and base-editing platform for functional genetic studies.

Programmable large-DNA writing in the human genome.

Recent advances in programmable large-DNA writing in the human genome are reviewed across four mechanistic categories: recombinase-, prime editing-, transposase-, and retrotransposon-mediated technologies.