gene editing

Loss of function of STAY-GREEN 1 enhances cold tolerance in tomato (Solanum lycopersicum L.) associated with jasmonic acid signaling and metabolic reprogramming.

The multi-line genetic and multi-omics evidence collectively confirms that SlSGR1 acts as a negative regulator of tomato cold adaptation via restraining JA-ICE-CBF signaling.

The Yield-Associated TaCOL-B5 Locus Activates Its Tightly Linked Target TaDRS1 to Restrict Root Apical Meristem Proliferation and Deep Rooting in Wheat.

Rooting depth underpins subsoil water capture and drought resilience in wheat, yet the regulators coupling root apical meristem (RAM) activity to vertical root growth remain largely unknown. We characterise Deep Root Suppressor 1 (TaDRS1; TraesCS7B01G400700), a transcriptional target of the yield-associated CONSTANS-li...

In Vitro Cellular Dynamics of Skin-Derived Fibroblasts of an MSTN-/-Gene-Edited Buffalo.

Overall, MSTN-/- fibroblasts display distinct cellular and epigenetic features with normal SCNT embryo production, supporting their utility for cellular reprograming studies.

Tropical vulnerability and temperate resilience: molecular and physiological insights into cold stress adaptation in oil palm.

Cold stress is a major abiotic constraint limiting the growth and productivity of oil palm (Elaeis guineensis). Its high sensitivity to chilling causes physiological impairment, metabolic disruption, and reduced oil yield and quality. This review summarizes physiological, biochemical, and molecular mechanisms of cold s...

CURRENT AND EMERGING PHARMACOTHERAPY FOR DYSLIPIDEMIA: A COMPREHENSIVE STUDY

Dyslipidemia is a primary driver of atherosclerotic cardiovascular disease. While statins reduce LDL-C and cardiovascular events, statin intolerance and failure to achieve guideline targets limit their utility. To review the mechanism, efficacy, safety, and clinical positioning of current and emerging antihyperlipidemi...

CURRENT AND EMERGING PHARMACOTHERAPY FOR DYSLIPIDEMIA: A COMPREHENSIVE STUDY

Dyslipidemia is a primary driver of atherosclerotic cardiovascular disease. While statins reduce LDL-C and cardiovascular events, statin intolerance and failure to achieve guideline targets limit their utility. To review the mechanism, efficacy, safety, and clinical positioning of current and emerging antihyperlipidemi...

Autonomous Multi-Agent Systems for Enterprise Decision-Making

An integrated conceptual framework is presented which maps layers of the MAS architecture to decision postures in the enterprise, a cross domain performance synthesis, and a research agenda for the next generation of enterprise-scale autonomous agent systems are presented.

From Chain-of-Note to Explainable Cognitive Prompting: Reproducible Multi-Layer Validation for Auditable LLM-Assisted PLC Programming : Structured Explainability and Deterministic Reasoning for Industrial PLC Applications

Explainability in Large Language Model (LLM)–assisted PLC programming is essential for industrial adoption, where engineers must understand, validate, and maintain generated control logic under strict safety and standardization constraints. Existing explainability-oriented prompting approaches such as Chain of Note (Co...

Standard Conformant Prompting (SCP): A Reproducible Framework for Compiler-Ready PLC Code Generation with Large Language Models : From Post-Hoc Verification to Standard-Driven Code Synthesis in Industrial Automation

Generating PLC programs with Large Language Models (LLMs) that are directly deployable in industrial toolchains remains challenging because outputs must satisfy IEC 61131-3 semantics and vendor-specific compilation constraints. Verification-centric prompting such as Chain-of-Verification (CoVe) can reduce reasoning err...

Active learning for interactive prompt clarification in safety-critical programmable logic controller code generation

CoT+ (Chain-of-Thought Extended): A reproducible multi-reasoning prompting architecture for deterministic PLC code generation

Strategic Temporal Opacity in Interstellar Interaction: Light-Speed Delay, Outdated Beliefs and Asynchronous Action in a Bayesian Game

Interstellar communication is not merely slow. It is strategically stale. A message received across distance reports a sender that may no longer occupy the same strategic state, while replies and irreversible actions are chosen on different local clocks. This paper develops a delayed Bayesian interaction game in which...