CladeForge 0.1.0 — first public release. CladeForge is a local-first, cross-platform desktop application for building, annotating and exporting phylogenetic trees with an integrated evolutionary semantic layer: the tree is treated as a hypothesis scaffold you can construct, compare and refine offline. Built on Tauri v2...
Zichao Zeng· Zenodo (CERN European Organi...· 0 citations
Barley is classified as malt or non-malt barley according to its end use, yet the role of starch characteristics in determining malt quality remains poorly understood. In this study, we systematically compared starch content, composition, granule structure, and thermal properties between six malt and six non-malt bar...
Meng-Di Li, Pei-Xin He, Kang-Feng Cai et al.· Frontiers in Plant Science· 0 citations
Processing Sanger DNA sequences remains a routine, yet technically demanding step in many biodiversity and ecological studies, particularly when barcoding large numbers of environmental samples. Manual inspection and editing of trace files, DNA sequence alignment and classification using taxonomic reference databases a...
Thomas Brekke, Thomas Weeks, Robert Barber et al.· Biodiversity Data Journal· 0 citations
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variant-fm-benchmark 3.0.1: code, data and every output of the study "Evidence strength of splice-region variant effect predictors assessed against saturation genome editing data in seven cancer susceptibility genes" (N. Zhang), with one command that rebuilds every output from public sources and checks it against the a...
Ningyi Zhang· Zenodo (CERN European Organi...· 0 citations
Human genetic studies have identified key regulators of fetal haemoglobin (HbF) expression, including BCL11A, resulting in therapeutic advances1-8. Yet the mechanisms by which HbF expression is activated remain incompletely understood9. Here we conduct a large multi-ancestry genome-wide association study of HbF levels...
Chun-Jie Guo, U. Arora, Xiao-Heng Cheng et al.· Nature· 0 citations
GATA2 (GATA binding protein 2) deficiency is a severe immunodeficiency caused by heterozygous variants in the gene encoding the transcription factor GATA2. Ex vivo gene editing of a patient's own CD34+ hematopoietic stem and progenitor cells (HSPCs) could provide curative treatment. However, current methods that rely o...
J. H. Wolff, T. W. Skov, S. R. Dorset et al.· Science Translational Medici...· 0 citations
Beneficial microbes from soil or marine habitats are promising sources for discovery of new bioactive compounds for medicine and agriculture, largely through biosynthetic gene clusters (BGCs) that encode the production of complex natural products for drug and antibiotic discovery. However, most BGCs are transcription...
R. Santhoshkumar, Hafid Mohamed, M. Jemo· Frontiers in Microbiology· 0 citations
Non-obstructive azoospermia (NOA) represents the most severe male infertility. Although microsurgical testicular sperm extraction combined with intracytoplasmic sperm injection offers opportunities, approximately 50% of NOA patients still fail to obtain sperm for clinical treatments. Fortunately, the emergence of preci...
Man-Xi Jiang, Tao Jing, Huai L. Feng et al.· Frontiers in Genome Editing· 0 citations
Cell and gene therapies hold great promise for treating monogenic disorders, yet their preclinical evaluation remains limited by the lack of scalable, human-specific models. Here we establish a patient-derived teratoma xenograft platform as a proof-of-concept system to evaluate ex vivo and in vivo therapeutic strategie...
Mihn Jeong Park, H. Kim, Yuna Hwang et al.· Experimental and Molecular M...· 0 citations
Gaucher disease (GD) is caused by recessive mutations in the GBA1 gene (Glucosylceramidase beta 1) generating lysosomal accumulation of glucosylceramides. Bone phenotypes related to GD include Erlenmeyer flask deformity, osteosclerosis, osteonecrosis, osteopenia, and bone pain. Lysosomes modulate osteoclast differentia...
J. Patiño-Salazar, J. D. Gutiérrez-Ávila, S. Heredero-Jiménez et al.· Calcified Tissue Internation...· 0 citations
Exploring how generative AI could make machine vision more accessible to businesses. The post GenEye in a Box: Making Machine Vision Something You Can Just Ask For appeared first on GPT-Lab.