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gene editing

1,393 papers

#gene editing Open access Sep 2026

CladeForge

CladeForge 0.1.0 — first public release. CladeForge is a local-first, cross-platform desktop application for building, annotating and exporting phylogenetic trees with an integrated evolutionary semantic layer: the tree is treated as a hypothesis scaffold you can construct, compare and refine offline. Built on Tauri v2...

Zichao Zeng · 0 citations
#gene editing Open access Sep 2026

Starch characteristics distinguish malt from non-malt barley and can be modulated via SBEIIb promoter editing

Barley is classified as malt or non-malt barley according to its end use, yet the role of starch characteristics in determining malt quality remains poorly understood. In this study, we systematically compared starch content, composition, granule structure, and thermal properties between six malt and six non-malt bar...

Meng-Di Li, Pei-Xin He, Kang-Feng Cai et al. · 0 citations
#gene editing Open access Sep 2026

Data and code for "Replication-driven mutation spectrum asymmetry causes GC-skew in bacterial genomes"

Replication-driven mutation spectrum asymmetry causes GC-skew in bacterial genomesThis repository contains the raw data, analysis scripts, output results and supplementary materials supporting the manuscript "Replication-driven mutation spectrum asymmetry causes GC-skew in bacterial genomes". The codebase analyzes prev...

Eldar Badamshin, Alexei Skudnov, Mato Lagator et al. · 0 citations
#gene editing Open access Sep 2026

MycorrhizaTracer: A bioinformatic pipeline for fungi and plant classification of Sanger DNA sequences

Processing Sanger DNA sequences remains a routine, yet technically demanding step in many biodiversity and ecological studies, particularly when barcoding large numbers of environmental samples. Manual inspection and editing of trace files, DNA sequence alignment and classification using taxonomic reference databases a...

Thomas Brekke, Thomas Weeks, Robert Barber et al. · 0 citations
#gene editing Open access Sep 2026

variant-fm-benchmark: evidence strength of splice-region variant effect predictors against saturation genome editing functional assays

variant-fm-benchmark 3.0.1: code, data and every output of the study "Evidence strength of splice-region variant effect predictors assessed against saturation genome editing data in seven cancer susceptibility genes" (N. Zhang), with one command that rebuilds every output from public sources and checks it against the a...

Ningyi Zhang · 0 citations
#gene editing Open access Sep 2026

Data and code for "Replication-driven mutation spectrum asymmetry causes GC-skew in bacterial genomes"

Replication-driven mutation spectrum asymmetry causes GC-skew in bacterial genomesThis repository contains the raw data, analysis scripts, output results and supplementary materials supporting the manuscript "Replication-driven mutation spectrum asymmetry causes GC-skew in bacterial genomes". The codebase analyzes prev...

Eldar Badamshin, Alexei Skudnov, Mato Lagator et al. · 0 citations
#gene editing Open access Sep 2026

Human genetics implicates a BACH2-NRF2 axis in fetal haemoglobin activation.

Human genetic studies have identified key regulators of fetal haemoglobin (HbF) expression, including BCL11A, resulting in therapeutic advances1-8. Yet the mechanisms by which HbF expression is activated remain incompletely understood9. Here we conduct a large multi-ancestry genome-wide association study of HbF levels...

Chun-Jie Guo, U. Arora, Xiao-Heng Cheng et al. · 0 citations
#gene editing Sep 2026

Prime editing of human hematopoietic stem cells for correction of GATA2 deficiency.

GATA2 (GATA binding protein 2) deficiency is a severe immunodeficiency caused by heterozygous variants in the gene encoding the transcription factor GATA2. Ex vivo gene editing of a patient's own CD34+ hematopoietic stem and progenitor cells (HSPCs) could provide curative treatment. However, current methods that rely o...

J. H. Wolff, T. W. Skov, S. R. Dorset et al. · 0 citations
#gene editing Review Open access Sep 2026

Integrated multi-omics and genome mining strategies for activating cryptic polyketide biosynthetic gene clusters in Streptomyces: an overview

Beneficial microbes from soil or marine habitats are promising sources for discovery of new bioactive compounds for medicine and agriculture, largely through biosynthetic gene clusters (BGCs) that encode the production of complex natural products for drug and antibiotic discovery. However, most BGCs are transcription...

R. Santhoshkumar, Hafid Mohamed, M. Jemo · 0 citations
#gene editing Review Open access Sep 2026

Gene therapy for non-obstructive azoospermia: therapeutic avenues and translational pathway to clinical application

Non-obstructive azoospermia (NOA) represents the most severe male infertility. Although microsurgical testicular sperm extraction combined with intracytoplasmic sperm injection offers opportunities, approximately 50% of NOA patients still fail to obtain sperm for clinical treatments. Fortunately, the emergence of preci...

Man-Xi Jiang, Tao Jing, Huai L. Feng et al. · 0 citations
#gene editing Open access Oct 2026

Patient-derived teratomas as a humanized platform for dystrophin restoration by ex vivo cell therapy and in vivo base editing.

Cell and gene therapies hold great promise for treating monogenic disorders, yet their preclinical evaluation remains limited by the lack of scalable, human-specific models. Here we establish a patient-derived teratoma xenograft platform as a proof-of-concept system to evaluate ex vivo and in vivo therapeutic strategie...

Mihn Jeong Park, H. Kim, Yuna Hwang et al. · 0 citations
#gene editing Open access Oct 2026

Generation and Characterization of an Osteoclastic Cell Model of Gaucher’s Bone Disease

Gaucher disease (GD) is caused by recessive mutations in the GBA1 gene (Glucosylceramidase beta 1) generating lysosomal accumulation of glucosylceramides. Bone phenotypes related to GD include Erlenmeyer flask deformity, osteosclerosis, osteonecrosis, osteopenia, and bone pain. Lysosomes modulate osteoclast differentia...

J. Patiño-Salazar, J. D. Gutiérrez-Ávila, S. Heredero-Jiménez et al. · 0 citations

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Google DeepMind Blog Sep 30, 2026

Introducing SynthID Bio

Proof of concept for watermarking AI-generated proteins while preserving biological function.

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