Author

Xiaoyu Yang

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#gene editing Open access Oct 2026

Alzheimer's disease target and drug discovery by leveraging multiomics and electronic health data.

Despite prolific genomic data from individuals with Alzheimer's disease (AD), translation into treatments has lagged. Here we applied Mendelian randomization to multiple AD genome-wide association studies and functional multiomics datasets to nominate druggable targets, identifying 19 targets for individuals of Europea...

Yuan Hou, Yi-Chen Li, Peng-Yue Zhang et al. · Nature Neuroscience · 0 citations

Aug 2026

Transferable genetic toolsets for nonmodel gut Clostridia enable in vivo reversible control of metabolite production.

This work identifies a panel of strong constitutive promoters that drive robust gene expression across diverse clostridial strains and develops an inducible promoter system that enables precise, tunable gene regulation and facilitates the implementation of CRISPR-Cas gene-deletion systems.

Ting-Ting Li, Xi Chen, Fang Wang et al. · Nature Biotechnology · 0 citations