TL;DR
The potential of single-cell miRNA profiling to contribute to precision medicine and therapeutic development is outlined, including its possible use in biomarker discovery, monitoring tumor heterogeneity, and informing personalized treatment strategies.
This chapter includes step-by-step protocols, example R code, and recommendations for integrating additional data layers such as copy number variation and DNA methylation, with the goal of improving the robustness and interpretability of miRNA-based analyses in cancer.
The spatial organization of post-transcriptional regulation is a fundamental yet difficult to access layer of tissue biology. MicroRNAs (miRNAs) are small RNAs with a key role in post-transcriptional regulation, but their short length has excluded them from spatial profiling technologies, leaving them largely unexplore...
This review focuses on druggable functional RNAs and discusses current and emerging technologies, as well as the scope for their potential clinical utility and targeted treatment, and highlights the most studied optimization strategies and delivery systems designed to enhance the efficacy and tissue-specific delivery o...
The biogenesis and biological functions of miRNAs are discussed and their regulatory roles in the pathogenesis of rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, multiple sclerosis, psoriasis, systemic lupus erythematosus, and atopic dermatitis are examined.
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