Author

K. Brennand

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Systematic Dissection of Key Driver Perturbation Signatures in Single Cells via ECCITE-seq.

An ECCITE-seq framework is described to characterize the transcriptomic consequences of perturbing multiple neuronal key driver genes associated with Alzheimer's disease (AD) in human-induced pluripotent stem cell (hiPSC)-derived neurons and allows for the assessment of the regulatory impact of candidate genes implicat...

Jing-Long Zhang, K. Brennand, Bin Zhang et al. · Methods in molecular biology · 0 citations

#gene editing Open access Sep 2026

Reverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency

The results reveal a unique human mechanism of disease and offer therapeutic insight for this inflammasomopathy and CRISPR editing of human CD34+ hematopoietic stem and progenitor cells (HSPCs) led to very efficient and persistent gene deletion in vivo.

Tian-Li Xiao, J. R. Brewer, Maximillian J. Carlino et al. · Journal of Clinical Investig... · 0 citations