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Light is shed on the mechanistic link between LDCD and oncogenesis, providing a rationale for the development of targeted antitumor strategies and outlines future research directions.
It is well established that the tumor microenvironment (TME) plays a dynamic role in breast cancer progression. Stromal components of the TME, including fibroblasts and the extracellular matrix (ECM), provide biophysical and biochemical cues to drive tumor cell proliferation and invasion. However, how the interplay bet...
Emerging evidence now reveals that pyroptosis exhibits dual functionality through its capacity to reshape the tumor immune microenvironment, and the cytotoxicity and immunotherapeutic response rate of cytotoxic T cells are significantly enhanced by activation of the T cell receptor signaling pathway and cytokine networ...
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