Oct 2026· Apoptosis· Vol 31· 0 citations· 181 references
Medicine
TL;DR
Light is shed on the mechanistic link between LDCD and oncogenesis, providing a rationale for the development of targeted antitumor strategies and outlines future research directions.
Lysosomes are critical cellular organelles that not only regulate metabolic regulation but also play pivotal roles in cell death, signal transduction, and tumorigenesis. The various ion channels expressed on the lysosomal membrane are central to these physiological functions; they intricately maintain lysosomal pH home...
Na Luo, Qiu-Xiang Wang, Jun Zhang et al.· Frontiers in Pharmacology· 0 citations
Current evidence is brought together to provide a comprehensive understanding of how CMA contributes to the Hallmarks of Cancer, including sustained proliferative signaling, resistance to cell death, metabolic reprogramming, invasion and metastasis, immune evasion, and the enabling characteristics of genome instability...
Meenakshi Tiwari, Lokendra Kumar Sharma, Bandana Chakravarti et al.· Frontiers in Oncology· 0 citations
Malignant progression and limited therapeutic response in gastric cancer (GC) cannot be explained solely by increased proliferation or oncogenic alterations. Instead, they reflect how tumor cells regulate their death threshold under sustained damage, metabolic stress and immune pressure. Evidence indicates that GC cell...
Meng-Ru Liu, Zhu-Jun Wu, Qiao Chen et al.· International Journal of Mol...· 0 citations
Evasion of apoptosis is a typical feature of malignant tumors developing to survive therapeutic stress. As a result, chemotherapeutic drugs that primarily induce apoptosis can no longer effectively kill tumor cells, which brings challenges to clinical cancer treatment. Recent evidence indicates that targeting key nodes...
Ting-Ting Liu, Yi-Wu Dang, Wen Zhang et al.· Biochimica et biophysica act...· 0 citations
Receptor-interacting protein kinase 1 (RIPK1) plays a pivotal role in regulating cell survival and death, thereby exerting complex and multifaceted functions in the initiation and progression of cancer. Its expression is frequently dysregulated across diverse malignancies and correlates strongly with poor prognosis, hi...
Jing-Yu Luo, Shu-Ya Song, Ze-Kun Li et al.· Cellular Signalling· 0 citations
Apoptosis is a tightly regulated form of programmed cell death essential for tissue homeostasis and genomic integrity. Its dysregulation contributes to diverse pathological conditions, particularly cancer, where evasion of apoptosis enables malignant transformation, tumour progression, immune escape, and therapeutic re...
Akhila Chagalamari, Gaurav Rangari, Bhaskar S. Rao et al.· Perspectives In Medical Rese...· 0 citations
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